{"id":1127,"date":"2022-03-23T14:40:13","date_gmt":"2022-03-23T14:40:13","guid":{"rendered":"https:\/\/lieuphapyhoctaitao.com\/?p=1127"},"modified":"2022-03-23T14:40:13","modified_gmt":"2022-03-23T14:40:13","slug":"thong-tin-y-hoc-exosome-va-exosome-te-bao-goc-trung-mo","status":"publish","type":"post","link":"https:\/\/lieuphapyhoctaitao.com\/?p=1127","title":{"rendered":"Th\u00f4ng tin y h\u1ecdc: Exosome v\u00e0 exosome t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4"},"content":{"rendered":"<p style=\"text-align: justify;\">C\u00e1c t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3 ch\u00fang ta sinh ra \u0111\u1ec3 th\u1ef1c hi\u1ec7n m\u1ed9t ch\u1ee9c n\u0103ng nh\u1ea5t \u0111\u1ecbnh m\u00e0 kh\u00f4ng th\u1ec3 thay th\u1ebf \u0111\u01b0\u1ee3c. Trong \u0111\u00f3, c\u00f3 m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o \u01b0u vi\u1ec7t h\u01a1n c\u1ea3, \u0111\u00f3 l\u00e0 T\u1ebf b\u00e0o g\u1ed1c v\u1edbi kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a \u2013 \u0111\u00e3 tr\u1edf th\u00e0nh n\u1ec1n m\u00f3ng c\u1ee7a m\u1ecdi t\u1ebf b\u00e0o, m\u00f4 v\u00e0 c\u01a1 quan trong c\u01a1 th\u1ec3. Nh\u1edd \u0111\u00f3 m\u00e0 t\u1ebf b\u00e0o g\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c \u1ee9ng d\u1ee5ng hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec1u b\u1ec7nh l\u00fd \u1edf ng\u01b0\u1eddi.<\/p>\n<p style=\"text-align: justify;\">Ti\u1ebfp n\u1ed1i nh\u1eefng th\u00e0nh t\u1ef1u c\u1ee7a li\u1ec7u ph\u00e1p T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong l\u0129nh v\u1ef1c c\u1ed9t s\u1ed1ng, x\u01b0\u01a1ng kh\u1edbp v\u00e0 ch\u1ed1ng l\u00e3o h\u00f3a l\u00e0m \u0111\u1eb9p, c\u00f4ng ty REGENMEDIC \u0111\u00e3 \u0111em \u0111\u1ebfn m\u1ed9t \u201cg\u01b0\u01a1ng m\u1eb7t s\u00e1ng gi\u00e1\u201d v\u1edbi ti\u1ec1m n\u0103ng \u1ee9ng d\u1ee5ng kh\u00f4ng thua k\u00e9m g\u00ec mang t\u00ean EXOSOME. C\u00f4ng ngh\u1ec7 m\u1edbi n\u00e0y \u0111em \u0111\u1ebfn nhi\u1ec1u l\u1ef1a ch\u1ecdn v\u1ec1 c\u00e1c li\u1ec7u ph\u00e1p y h\u1ecdc t\u00e1i sinh cho kh\u00e1ch h\u00e0ng.<\/p>\n<p style=\"text-align: justify;\">\u00a0EXOSOME l\u00e0 g\u00ec?<\/p>\n<p style=\"text-align: justify;\">\u25ba Ch\u1ea5t ti\u1ebft c\u1ee7a t\u1ebf b\u00e0o<\/p>\n<p style=\"text-align: justify;\">Exosome l\u00e0 nh\u1eefng t\u00fai ngo\u1ea1i b\u00e0o \u0111\u01b0\u1ee3c t\u1ebf b\u00e0o s\u1ed1ng trong c\u01a1 th\u1ec3 ti\u1ebft ra, v\u00e0 \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh trong c\u00e1c d\u1ecbch c\u01a1 th\u1ec3 nh\u01b0 m\u00e1u, n\u01b0\u1edbc ti\u1ec3u, n\u01b0\u1edbc b\u1ecdt\u2026 M\u1ed7i ph\u00e2n t\u1eed exosome c\u00f3 k\u00edch th\u01b0\u1edbc t\u1eeb 40 \u0111\u1ebfn 150 nanomet (nm), c\u1ea5u t\u1ea1o b\u00ean trong ch\u1ee9a c\u00e1c DNA, mRNA, miRNA, c\u00e1c lo\u1ea1i protein, cytokines v\u00e0 c\u00e1c nh\u00e2n t\u1ed1 sinh tr\u01b0\u1edfng. Mang nh\u1eefng \u0111\u1eb7c t\u00ednh t\u01b0\u01a1ng t\u1ef1 t\u1ebf b\u00e0o m\u1eb9, c\u00e1c exosome khi \u0111i v\u00e0o c\u01a1 th\u1ec3 s\u1ebd gi\u00fap t\u00e1i t\u1ea1o v\u00e0 s\u1eeda ch\u1eefa c\u00e1c t\u1ebf b\u00e0o b\u1ecb t\u1ed5n th\u01b0\u01a1ng v\u00e0 suy y\u1ebfu th\u00f4ng qua c\u00e1c ch\u1ee9c n\u0103ng sinh h\u1ecdc bao g\u1ed3m bi\u1ec7t h\u00f3a \u0111a d\u00f2ng, gi\u1ea3i ph\u00f3ng cytokine v\u00e0 t\u0103ng sinh t\u1ebf b\u00e0o.<\/p>\n<p style=\"text-align: justify;\">\u25ba C\u1ea7u n\u1ed1i gi\u1eefa c\u00e1c t\u1ebf b\u00e0o<\/p>\n<p style=\"text-align: justify;\">M\u1ed9t trong nh\u1eefng vai tr\u00f2 r\u1ea5t quan tr\u1ecdng c\u1ee7a exosome \u0111\u00f3 l\u00e0 kh\u1ea3 n\u0103ng di chuy\u1ec3n \u0111\u1ebfn ph\u1ea7n l\u1edbn c\u00e1c m\u00f4 c\u1ee7a c\u01a1 th\u1ec3 v\u00e0 truy\u1ec1n t\u1ea3i th\u00f4ng tin gi\u1eefa c\u00e1c t\u1ebf b\u00e0o.<\/p>\n<p style=\"text-align: justify;\">Tr\u00ean b\u1ec1 m\u1eb7t c\u00e1c t\u1ebf b\u00e0o lu\u00f4n c\u00f3 c\u00e1c protein \u0111\u1ea3m nh\u1eadn nhi\u1ec7m v\u1ee5 nh\u1eadn t\u00edn hi\u1ec7u t\u1eeb m\u00f4i tr\u01b0\u1eddng ngo\u1ea1i b\u00e0o v\u00e0 sau \u0111\u00f3 gi\u1ea3i ph\u00f3ng exosome. Exosome th\u01b0\u1eddng c\u00f3 c\u00e1c \u0111\u1eb7c t\u00ednh gi\u1ed1ng v\u1edbi t\u1ebf b\u00e0o b\u1ed1 m\u1eb9 c\u1ee7a ch\u00fang. T\u1ebf b\u00e0o b\u1ed1 m\u1eb9 truy\u1ec1n cho exosome c\u00e1c ph\u00e2n t\u1eed di truy\u1ec1n nh\u01b0 DNA, RNA, protein, v\u1eadt ch\u1ea5t chuy\u1ec3n h\u00f3a v\u00e0 b\u00e0i xu\u1ea5t ch\u00fang v\u00e0o c\u01a1 th\u1ec3. Khi \u1ea5y, exosome s\u1ebd \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh trong d\u1ecbch th\u1ec3 v\u00e0 g\u1eb7p c\u00e1c t\u1ebf b\u00e0o \u0111\u00edch, ch\u00fang s\u1ebd ti\u1ebft ra c\u00e1c t\u00edn hi\u1ec7u \u0111\u1ec3 trao \u0111\u1ed5i th\u00f4ng tin v\u1edbi t\u1ebf b\u00e0o \u0111\u00edch.<\/p>\n<p style=\"text-align: justify;\">\u0110\u1eb7c t\u00ednh c\u1ee7a Exosome<\/p>\n<p style=\"text-align: justify;\">* \u0110\u1ecbnh h\u01b0\u1edbng m\u1ee5c ti\u00eau<\/p>\n<p style=\"text-align: justify;\">\u0110a ph\u1ea7n c\u00e1c t\u1ebf b\u00e0o c\u00f3 th\u1ec3 s\u1ea3n sinh exosomes, ch\u00fang ch\u1ec9 \u0111\u1ea1o c\u00f3 ch\u1ecdn l\u1ecdc thay v\u00ec t\u01b0\u01a1ng t\u00e1c ng\u1eabu nhi\u00ean v\u1edbi c\u00e1c t\u1ebf b\u00e0o x\u1ea3y ra g\u1ea7n \u0111\u00f3.<\/p>\n<p style=\"text-align: justify;\">* K\u00edch th\u01b0\u1edbc h\u1ea1t nano<\/p>\n<p style=\"text-align: justify;\">K\u00edch th\u01b0\u1edbc t\u1ebf b\u00e0o th\u00f4ng th\u01b0\u1eddng l\u00e0 kho\u1ea3ng 10,000-30,000 nanomet (nm) nh\u01b0ng exosomes ch\u1ec9 kho\u1ea3ng t\u1eeb 40-150 nanomet (nm), t\u1ee9c l\u00e0 kho\u1ea3ng 1\/200 k\u00edch th\u01b0\u1edbc c\u1ee7a t\u1ebf b\u00e0o. Exosomes c\u00f3 c\u1ea5u tr\u00fac m\u00e0ng lipid k\u00e9p m\u00e0 c\u00f3 th\u1ec3 d\u1ec5 d\u00e0ng \u0111i qua kho\u1ea3ng tr\u1ed1ng c\u1ee7a t\u1ebf b\u00e0o n\u1ed9i m\u00f4 \u0111\u1ec3 t\u1edbi t\u1ebf b\u00e0o \u0111\u00edch, v\u00ec th\u1ebf ch\u00fang c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng t\u1ed1t trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi. H\u01a1n n\u1eefa, m\u1ed9t v\u00e0i nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng exosomes c\u00f3 th\u1ec3 d\u1ec5 d\u00e0ng \u0111i qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o (BBB) \u0111\u1ec3 t\u1edbi t\u1ebf b\u00e0o \u0111\u00edch.<\/p>\n<p style=\"text-align: justify;\">* \u00cdt r\u1ee7i ro b\u1ecb h\u1ec7 mi\u1ec5n d\u1ecbch \u0111\u00e0o th\u1ea3i<\/p>\n<p style=\"text-align: justify;\">Exosomes kh\u00f4ng ph\u1ea3i l\u00e0 t\u1ebf b\u00e0o, ch\u1ec9 \u0111\u00f3ng vai tr\u00f2 nh\u01b0 l\u00e0 ch\u1ea5t mang, xu\u1ea5t hi\u1ec7n \u00edt kh\u00e1ng nguy\u00ean tr\u00ean b\u1ec1 m\u1eb7t m\u00e0ng ngo\u00e0i, h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch kh\u00f3 nh\u1eadn bi\u1ebft v\u00e0 hi\u1ec7n di\u1ec7n r\u1ee7i ro th\u1ea5p h\u01a1n khi truy\u1ec1n v\u00e0o c\u01a1 th\u1ec3 ng\u01b0\u1eddi.<\/p>\n<p style=\"text-align: justify;\">\u00a0Exosome t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 (MSC \u2013 EXOSOME)<\/p>\n<p style=\"text-align: justify;\">Exosome t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 l\u00e0 ch\u1ea5t ti\u1ebft t\u1eeb t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4, ch\u1ee9a ch\u1ee7 y\u1ebfu l\u00e0 miRNA v\u00e0 c\u00e1c lo\u1ea1i protein. Ngo\u00e0i ra c\u00f2n ch\u1ee9a cytokine v\u00e0 c\u00e1c nh\u00e2n t\u1ed1 sinh tr\u01b0\u1edfng. V\u00ec l\u00e0 ch\u1ea5t ti\u1ebft c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 n\u00ean MSC-exosome \u0111\u01b0\u1ee3c ch\u1ee9ng minh an to\u00e0n, th\u1eadm ch\u00ed c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb GvHD trong c\u1ea5y gh\u00e9p.<\/p>\n<p style=\"text-align: justify;\">C\u00e1c exsome c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb MSC th\u1ef1c hi\u1ec7n c\u00e1c ch\u1ee9c n\u0103ng sinh h\u1ecdc kh\u00e1c nhau bao g\u1ed3m bi\u1ec7t h\u00f3a \u0111a d\u00f2ng, gi\u1ea3i ph\u00f3ng cytokine, t\u0103ng sinh t\u1ebf b\u00e0o v\u00e0 \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch. Do \u0111\u00f3 c\u00e1c MSC-exosome r\u1ea5t h\u1ea5p d\u1eabn gi\u1edbi khoa h\u1ecdc v\u00ec ti\u1ec1m n\u0103ng c\u1ee7a ch\u00fang trong \u1ee9ng d\u1ee5ng \u0111i\u1ec1u tr\u1ecb b\u1ec7nh.<\/p>\n<p style=\"text-align: justify;\">\u00a0L\u1ee3i th\u1ebf c\u1ee7a MSC- EXOSOME<\/p>\n<ul>\n<li style=\"text-align: justify;\">Exosome kh\u00f4ng t\u1ef1 ph\u00e2n chia, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e2n t\u00e1ch m\u1ed9t c\u00e1ch an to\u00e0n.<\/li>\n<li style=\"text-align: justify;\">Qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb \u0111\u01a1n gi\u1ea3n h\u01a1n so v\u1edbi li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c.<\/li>\n<li style=\"text-align: justify;\">\u00cdt nguy c\u01a1 g\u00e2y ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch h\u01a1n.<\/li>\n<li style=\"text-align: justify;\">C\u00f3 th\u1ec3 bi\u1ec3n \u0111\u1ed5i theo m\u1ee5c \u0111\u00edch s\u1eed d\u1ee5ng, m\u1ee5c ti\u00eau \u0111\u00edch, c\u00f3 kh\u1ea3 n\u0103ng v\u1eadn chuy\u1ec3n c\u00e1c lo\u1ea1i ho\u1ea1t ch\u1ea5t hi\u1ec7u qu\u1ea3 h\u01a1n.<\/li>\n<li style=\"text-align: justify;\">Do c\u00f3 k\u00edch th\u01b0\u1edbc nh\u1ecf n\u00ean MSC \u2013 Exosome c\u00f3 th\u1ec3 ti\u1ebfp c\u1eadn \u0111\u1ebfn c\u1ea3 nh\u1eefng v\u1ecb tr\u00ed m\u00e0 t\u1ebf b\u00e0o g\u1ed1c kh\u00f4ng \u0111\u1ebfn \u0111\u01b0\u1ee3c, gi\u00fap t\u0103ng hi\u1ec7u qu\u1ea3 sau tr\u1ecb li\u1ec7u.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>C\u00e1c t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3 ch\u00fang ta sinh ra \u0111\u1ec3 th\u1ef1c hi\u1ec7n m\u1ed9t ch\u1ee9c n\u0103ng nh\u1ea5t \u0111\u1ecbnh m\u00e0 kh\u00f4ng th\u1ec3 thay th\u1ebf \u0111\u01b0\u1ee3c. Trong \u0111\u00f3, c\u00f3 m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o \u01b0u vi\u1ec7t h\u01a1n c\u1ea3, \u0111\u00f3 l\u00e0 T\u1ebf b\u00e0o g\u1ed1c v\u1edbi kh\u1ea3 n\u0103ng bi\u1ec7t h\u00f3a \u2013 \u0111\u00e3 tr\u1edf th\u00e0nh n\u1ec1n m\u00f3ng c\u1ee7a m\u1ecdi t\u1ebf b\u00e0o, [&#8230;]\n","protected":false},"author":2,"featured_media":192,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[11],"tags":[],"_links":{"self":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/1127"}],"collection":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1127"}],"version-history":[{"count":1,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/1127\/revisions"}],"predecessor-version":[{"id":1128,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/1127\/revisions\/1128"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/media\/192"}],"wp:attachment":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1127"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1127"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}