T\u1ebf b\u00e0o NK (Natural Killer) l\u00e0 m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch b\u1ea9m sinh c\u00f3 kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0, t\u1ebf b\u00e0o nhi\u1ec5m virus m\u00e0 kh\u00f4ng c\u1ea7n qu\u00e1 tr\u00ecnh m\u1eabn c\u1ea3m tr\u01b0\u1edbc \u0111\u00f3. Nh\u1edd c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng \u0111\u1eb7c bi\u1ec7t n\u00e0y, t\u1ebf b\u00e0o NK \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 \u1ee9ng d\u1ee5ng r\u1ed9ng r\u00e3i trong y h\u1ecdc, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch.<\/p>\n
1. \u1ee8ng d\u1ee5ng c\u1ee7a t\u1ebf b\u00e0o NK<\/strong><\/span><\/p>\n 1.1. \u0110i\u1ec1u tr\u1ecb ung th\u01b0<\/strong><\/span><\/p>\n Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch NK t\u1ef1 th\u00e2n: T\u1ebf b\u00e0o NK \u0111\u01b0\u1ee3c t\u00e1ch t\u1eeb m\u00e1u b\u1ec7nh nh\u00e2n, nu\u00f4i c\u1ea5y v\u00e0 ho\u1ea1t h\u00f3a trong ph\u00f2ng th\u00ed nghi\u1ec7m, sau \u0111\u00f3 truy\u1ec1n l\u1ea1i v\u00e0o c\u01a1 th\u1ec3 \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0.Li\u1ec7u ph\u00e1p NK \u0111\u1ed3ng lo\u00e0i: S\u1eed d\u1ee5ng t\u1ebf b\u00e0o NK t\u1eeb ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh (hi\u1ebfn t\u1eb7ng) \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n ung th\u01b0.K\u1ebft h\u1ee3p v\u1edbi kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng (mAb): T\u1ebf b\u00e0o NK c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t m\u1ea1nh h\u01a1n nh\u1edd c\u01a1 ch\u1ebf ADCC (Antibody-Dependent Cellular Cytotoxicity) khi k\u1ebft h\u1ee3p v\u1edbi c\u00e1c kh\u00e1ng th\u1ec3 \u0111\u1eb7c hi\u1ec7u nh\u01b0 Rituximab, Trastuzumab.D\u1eabn truy\u1ec1n gene (CAR-NK): T\u01b0\u01a1ng t\u1ef1 nh\u01b0 CAR-T, t\u1ebf b\u00e0o NK \u0111\u01b0\u1ee3c c\u1ea3i ti\u1ebfn b\u1eb1ng c\u00f4ng ngh\u1ec7 gene \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n 1.2. \u0110i\u1ec1u tr\u1ecb b\u1ec7nh do virus (HIV, COVID-19, vi\u00eam gan B, C, v.v.)<\/strong><\/span><\/p>\n T\u1ebf b\u00e0o NK c\u00f3 vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c nh\u1eadn di\u1ec7n v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o nhi\u1ec5m virus, gi\u00fap ki\u1ec3m so\u00e1t c\u00e1c b\u1ec7nh do virus g\u00e2y ra.C\u00e1c nghi\u00ean c\u1ee9u \u0111ang t\u1eadp trung v\u00e0o vi\u1ec7c t\u1ed1i \u01b0u h\u00f3a NK \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb HIV\/AIDS, vi\u00eam gan B m\u1ea1n t\u00ednh v\u00e0 COVID-19.<\/p>\n 1.3. \u0110i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh t\u1ef1 mi\u1ec5n<\/strong><\/span><\/p>\n T\u1ebf b\u00e0o NK kh\u00f4ng ch\u1ec9 ti\u00eau di\u1ec7t t\u00e1c nh\u00e2n g\u00e2y b\u1ec7nh m\u00e0 c\u00f2n c\u00f3 vai tr\u00f2 \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch, gi\u00fap ki\u1ec3m so\u00e1t ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch qu\u00e1 m\u1ee9c trong b\u1ec7nh t\u1ef1 mi\u1ec5n nh\u01b0 vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p, lupus ban \u0111\u1ecf h\u1ec7 th\u1ed1ng.NK c\u00f3 th\u1ec3 gi\u00fap c\u00e2n b\u1eb1ng h\u1ec7 mi\u1ec5n d\u1ecbch v\u00e0 ng\u0103n ch\u1eb7n t\u1ed5n th\u01b0\u01a1ng m\u00f4 do ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch qu\u00e1 m\u1ee9c.<\/p>\n 1.4. \u1ee8ng d\u1ee5ng trong y h\u1ecdc t\u00e1i t\u1ea1o<\/strong><\/span><\/p>\n NK c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 lo\u1ea1i b\u1ecf t\u1ebf b\u00e0o b\u1ecb t\u1ed5n th\u01b0\u01a1ng ho\u1eb7c tho\u00e1i h\u00f3a trong c\u00e1c b\u1ec7nh li\u00ean quan \u0111\u1ebfn l\u00e3o h\u00f3a.<\/p>\n","protected":false},"excerpt":{"rendered":" T\u1ebf b\u00e0o NK (Natural Killer) l\u00e0 m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch b\u1ea9m sinh c\u00f3 kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0, t\u1ebf b\u00e0o nhi\u1ec5m virus m\u00e0 kh\u00f4ng c\u1ea7n qu\u00e1 tr\u00ecnh m\u1eabn c\u1ea3m tr\u01b0\u1edbc \u0111\u00f3. Nh\u1edd c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng \u0111\u1eb7c bi\u1ec7t n\u00e0y, t\u1ebf b\u00e0o NK \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 […]\n","protected":false},"author":2,"featured_media":2141,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3,9,11],"tags":[],"_links":{"self":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2138"}],"collection":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2138"}],"version-history":[{"count":5,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2138\/revisions"}],"predecessor-version":[{"id":2293,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2138\/revisions\/2293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/media\/2141"}],"wp:attachment":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2138"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2138"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}