{"id":2142,"date":"2025-06-01T07:19:18","date_gmt":"2025-06-01T07:19:18","guid":{"rendered":"https:\/\/lieuphapyhoctaitao.com\/?p=2142"},"modified":"2025-09-18T15:21:00","modified_gmt":"2025-09-18T15:21:00","slug":"lieu-phap-truyen-te-bao-nk","status":"publish","type":"post","link":"https:\/\/lieuphapyhoctaitao.com\/?p=2142","title":{"rendered":"\ud83c\udfaf\ud83c\udfaf\ud83c\udfaf LI\u1ec6U PH\u00c1P TRUY\u1ec0N T\u1ebe B\u00c0O NK"},"content":{"rendered":"<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\">T\u1ebf b\u00e0o NK r\u1ea5t c\u1ea7n thi\u1ebft cho kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch ch\u1ed1ng ung th\u01b0. S\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a nhi\u1ec1u y\u1ebfu t\u1ed1 \u1ee9c ch\u1ebf trong TME \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 \u1ee9c ch\u1ebf ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o NK. Ngo\u00e0i ra, c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m sinh h\u1ecdc c\u1ee7a t\u1ebf b\u00e0o NK v\u00e0 c\u00e1c k\u1ef9 thu\u1eadt s\u1eeda \u0111\u1ed5i \u0111\u1ec3 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o NK \u0111\u01b0\u1ee3c th\u1ea3o lu\u1eadn r\u1ed9ng r\u00e3i. C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng s\u1eed d\u1ee5ng li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o NK \u0111\u01a1n l\u1ebb ho\u1eb7c k\u1ebft h\u1ee3p v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh v\u00e0 cho th\u1ea5y hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7y h\u1ee9a h\u1eb9n.<\/p>\n<h3 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"1Lieu_phap_truyen_te_bao_NK_dong_loai\"><\/span><span style=\"font-size: 110%;\">1.Li\u1ec7u ph\u00e1p truy\u1ec1n t\u1ebf b\u00e0o NK \u0111\u1ed3ng lo\u1ea1i<\/span><span class=\"ez-toc-section-end\"><\/span><\/h3><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u00d4\u0323I DUNG:<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2142\/#1Lieu_phap_truyen_te_bao_NK_dong_loai\" >1.Li\u1ec7u ph\u00e1p truy\u1ec1n t\u1ebf b\u00e0o NK \u0111\u1ed3ng lo\u1ea1i<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2142\/#2_Cytokine_tang_cuong_hoat_dong_cua_te_bao_NK_trong_co_the_song\" >2. Cytokine t\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o NK trong c\u01a1 th\u1ec3 s\u1ed1ng<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2142\/#21_Dieu_tri_bang_cytokine_dua_tren_IL-2\" >2.1. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng cytokine d\u1ef1a tr\u00ean IL-2<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2142\/#22_Dieu_tri_bang_cytokine_dua_tren_IL-15\" >2.2. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng cytokine d\u1ef1a tr\u00ean IL-15<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2142\/#Ket_luan\" >K\u1ebft lu\u1eadn<\/a><\/li><\/ul><\/nav><\/div>\n\n<p style=\"text-align: justify;\">Vi\u1ec7c truy\u1ec1n t\u1ebf b\u00e0o NK t\u1ef1 th\u00e2n \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p kh\u1ea3 thi, do s\u1ef1 ti\u1ec7n l\u1ee3i c\u1ee7a vi\u1ec7c t\u00ecm ngu\u1ed3n t\u1ebf b\u00e0o NK, kh\u00f4ng y\u00eau c\u1ea7u \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch v\u00e0 nguy c\u01a1 m\u1eafc b\u1ec7nh gh\u00e9p ch\u1ed1ng v\u1eadt ch\u1ee7 th\u1ea5p. Tuy nhi\u00ean, s\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o NK l\u01b0u h\u00e0nh t\u0103ng l\u00ean trong m\u00e1u ngo\u1ea1i vi kh\u00f4ng t\u1ea1o ra ph\u1ea3n \u1ee9ng \u0111i\u1ec1u tr\u1ecb mong \u0111\u1ee3i, c\u00f3 l\u1ebd l\u00e0 do \u1ee9c ch\u1ebf c\u00e1c ph\u00e2n t\u1eed HLA t\u1ef1 th\u00e2n. Ngo\u00e0i ra, so v\u1edbi t\u1ebf b\u00e0o NK \u0111\u1ed3ng lo\u1ea1i, t\u1ebf b\u00e0o NK t\u1ef1 th\u00e2n th\u01b0\u1eddng \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc nhi\u1ec1u v\u1edbi hi\u1ec7u qu\u1ea3 m\u1edf r\u1ed9ng v\u00e0 \u0111\u1ed9c t\u00ednh t\u1ebf b\u00e0o h\u1ea1n ch\u1ebf. Do \u0111\u00f3, nh\u1eefng h\u1ea1n ch\u1ebf n\u00e0y h\u1ea1n ch\u1ebf vi\u1ec7c ti\u1ebfp t\u1ee5c kh\u00e1m ph\u00e1 c\u00e1c d\u1ecbch truy\u1ec1n t\u1ebf b\u00e0o NK t\u1ef1 th\u00e2n.<\/p>\n<p style=\"text-align: justify;\">Trong li\u1ec7u ph\u00e1p truy\u1ec1n t\u1ebf b\u00e0o NK \u0111\u1ed3ng lo\u1ea1i, s\u1ef1 kh\u00f4ng ph\u00f9 h\u1ee3p gi\u1eefa c\u00e1c KIR \u1ee9c ch\u1ebf \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n tr\u00ean t\u1ebf b\u00e0o NK c\u1ee7a ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng v\u00e0 c\u00e1c ph\u1ed1i t\u1eed HLA c\u1ee7a ng\u01b0\u1eddi nh\u1eadn k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng c\u1ee7a t\u1ebf b\u00e0o NK. \u0110\u1ec3 tr\u00e1nh t\u00ecnh tr\u1ea1ng ng\u01b0\u1eddi nh\u1eadn t\u1eeb ch\u1ed1i mi\u1ec5n d\u1ecbch c\u00e1c t\u1ebf b\u00e0o NK \u0111\u1ed3ng lo\u1ea1i, c\u1ea7n ph\u1ea3i d\u00f9ng h\u00f3a tr\u1ecb li\u1ec7u kh\u00f4ng g\u00e2y suy t\u1ee7y tr\u01b0\u1edbc khi chuy\u1ec3n giao nu\u00f4i c\u1ea5y. Nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng b\u1ec7nh nh\u00e2n AML \u0111\u01b0\u1ee3c truy\u1ec1n t\u1ebf b\u00e0o NK \u0111\u1ed3ng lo\u1ea1i sau khi d\u00f9ng cyclophosphamide v\u00e0 fludarabine li\u1ec1u cao s\u1ebd \u0111\u1ea1t \u0111\u01b0\u1ee3c t\u00ecnh tr\u1ea1ng thuy\u00ean gi\u1ea3m ho\u00e0n to\u00e0n. \u0110\u00e1ng ch\u00fa \u00fd, ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb l\u00e0m suy gi\u1ea3m lympho g\u00f3p ph\u1ea7n l\u00e0m t\u0103ng \u0111\u00e1ng k\u1ec3 n\u1ed3ng \u0111\u1ed9 IL-15 n\u1ed9i sinh c\u1ea7n thi\u1ebft cho s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 t\u1ed3n t\u1ea1i c\u1ee7a t\u1ebf b\u00e0o NK c\u1ee7a ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng .<\/p>\n<h3 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"2_Cytokine_tang_cuong_hoat_dong_cua_te_bao_NK_trong_co_the_song\"><\/span>2. Cytokine t\u0103ng c\u01b0\u1eddng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o NK trong c\u01a1 th\u1ec3 s\u1ed1ng<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p style=\"text-align: justify;\">Cytokine c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch l\u00e0 c\u1ea7n thi\u1ebft \u0111\u1ec3 duy tr\u00ec s\u1ef1 s\u1ed1ng c\u00f2n, t\u0103ng sinh v\u00e0 tr\u01b0\u1edfng th\u00e0nh c\u1ee7a t\u1ebf b\u00e0o NK. C\u00e1c cytokine n\u00e0y bao g\u1ed3m IL-2, IL-15, IL-12, IL-21 v\u00e0 IL-18; IL-2 v\u00e0 IL-15 l\u00e0 nh\u1eefng cytokine \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i nh\u1ea5t. Ch\u00fang c\u1ea7n thi\u1ebft cho \u0111\u1ed9c t\u00ednh t\u1ebf b\u00e0o do NKG2D trung gian v\u00e0 ti\u1ebft IFN-\u03b3; do \u0111\u00f3, ch\u00fang \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i nh\u01b0 c\u00e1c ch\u1ea5t \u1ee7 tr\u01b0\u1edbc khi truy\u1ec1n t\u1ebf b\u00e0o NK ho\u1eb7c nh\u01b0 c\u00e1c t\u00e1c nh\u00e2n truy\u1ec1n. M\u1eb7c d\u00f9 c\u00f3 nh\u1eefng lo ng\u1ea1i v\u1ec1 hi\u1ec7u qu\u1ea3 v\u00e0 t\u00ednh an to\u00e0n, nhi\u1ec1u gi\u1ea3i ph\u00e1p kh\u00e1c nhau \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ec3 t\u1ed1i \u01b0u h\u00f3a hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<h4 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"21_Dieu_tri_bang_cytokine_dua_tren_IL-2\"><\/span><strong><span style=\"font-size: 140%;\">2.1. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng cytokine d\u1ef1a tr\u00ean IL-2<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p style=\"text-align: justify;\">IL-2 l\u00e0 cytokine \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n do kh\u1ea3 n\u0103ng \u0111\u1ea7y h\u1ee9a h\u1eb9n c\u1ee7a n\u00f3 trong vi\u1ec7c k\u00edch ho\u1ea1t kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch ch\u1ed1ng ung th\u01b0 v\u00e0 k\u00edch th\u00edch s\u1ea3n xu\u1ea5t c\u00e1c t\u1ebf b\u00e0o s\u00e1t th\u1ee7 \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t b\u1edfi lymphokine. Tuy nhi\u00ean, hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb b\u1ecb h\u1ea1n ch\u1ebf do th\u1ee5 th\u1ec3 c\u00f3 \u00e1i l\u1ef1c cao IL-2R\u03b1 (CD25), \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n c\u1ea1nh tranh tr\u00ean c\u00e1c t\u1ebf b\u00e0o Treg v\u00e0 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y do k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o n\u1ed9i m\u00f4 m\u1ea1ch m\u00e1u. Do \u0111\u00f3, c\u1ea7n ph\u1ea3i gi\u1ea3i quy\u1ebft nh\u1eefng thi\u1ebfu s\u00f3t n\u00e0y \u0111\u1ec3 c\u1ea3i thi\u1ec7n li\u1ec7u ph\u00e1p IL-2. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 thi\u1ebft k\u1ebf m\u1ed9t d\u1ea1ng \u0111\u1ed9t bi\u1ebfn c\u1ee7a IL-2 \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 &#8220;si\u00eau 2&#8221; c\u00f3 \u00e1i l\u1ef1c li\u00ean k\u1ebft t\u0103ng l\u00ean \u0111\u1ed1i v\u1edbi IL-2R\u03b2, gi\u00fap tr\u00e1nh s\u1ef1 can thi\u1ec7p c\u1ee7a c\u00e1c t\u1ebf b\u00e0o Treg v\u00e0 g\u00e2y ra s\u1ef1 m\u1edf r\u1ed9ng v\u01b0\u1ee3t tr\u1ed9i c\u0169ng nh\u01b0 c\u1ea3i thi\u1ec7n ho\u1ea1t \u0111\u1ed9ng ch\u1ed1ng ung th\u01b0 c\u1ee7a c\u00e1c t\u1ebf b\u00e0o NK . X\u00e9t \u0111\u1ebfn vi\u1ec7c c\u00e1c \u0111\u1ed9t bi\u1ebfn IL-2 t\u0103ng c\u01b0\u1eddng IL-2R\u03b2 kh\u00f4ng th\u1ec3 ch\u1eb7n ho\u00e0n to\u00e0n s\u1ef1 li\u00ean k\u1ebft gi\u1eefa Treg v\u00e0 IL-2, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 thi\u1ebft k\u1ebf m\u1ed9t protein h\u1ee3p nh\u1ea5t IL-2 k\u1ebft h\u1ee3p protein ph\u1ee9c h\u1ee3p t\u01b0\u01a1ng th\u00edch m\u00f4 ch\u00ednh lo\u1ea1i I c\u1ee7a orthopoxvirus ph\u1ed1i t\u1eed NKG2D c\u00f3 \u00e1i l\u1ef1c cao (OMCP) v\u1edbi c\u00e1c \u0111\u1ed9t bi\u1ebfn IL-2, l\u00e0m gi\u1ea3m \u00e1i l\u1ef1c \u0111\u1ed1i v\u1edbi IL-2R\u03b1. Protein h\u1ee3p nh\u1ea5t n\u00e0y k\u00edch ho\u1ea1t ch\u1ecdn l\u1ecdc c\u00e1c t\u1ebf b\u00e0o mang NKG2D thay v\u00ec c\u00e1c t\u1ebf b\u00e0o mang IL2 R\u03b1, kh\u00f4ng ch\u1ec9 th\u00fac \u0111\u1ea9y s\u1ef1 m\u1edf r\u1ed9ng v\u00e0 ho\u1ea1t h\u00f3a c\u1ee7a c\u00e1c t\u1ebf b\u00e0o NK m\u00e0 c\u00f2n tr\u00e1nh \u0111\u01b0\u1ee3c c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 h\u1ea1i do c\u00e1c t\u1ebf b\u00e0o Treg m\u1edf r\u1ed9ng g\u00e2y ra .<\/p>\n<p style=\"text-align: justify;\">Ngo\u00e0i li\u1ec7u ph\u00e1p \u0111\u01a1n tr\u1ecb, c\u00e1c li\u1ec7u ph\u00e1p IL-2 t\u1ed1i \u01b0u k\u1ebft h\u1ee3p v\u1edbi li\u1ec7u ph\u00e1p truy\u1ec1n t\u1ebf b\u00e0o NK \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ec3 k\u00edch th\u00edch ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o NK trong c\u01a1 th\u1ec3 s\u1ed1ng. Trong m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, protein h\u1ee3p nh\u1ea5t \u0111\u1ed9c t\u1ed1 b\u1ea1ch h\u1ea7u-IL-2 (IL2DT) trong truy\u1ec1n t\u1ebf b\u00e0o NK nu\u00f4i c\u1ea5y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n AML \u0111\u00e3 lo\u1ea1i b\u1ecf t\u1ebf b\u00e0o Treg v\u00e0 cho th\u1ea5y hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c c\u1ea3i thi\u1ec7n .<\/p>\n<h4 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"22_Dieu_tri_bang_cytokine_dua_tren_IL-15\"><\/span><span style=\"font-size: 140%;\">2.2. \u0110i\u1ec1u tr\u1ecb b\u1eb1ng cytokine d\u1ef1a tr\u00ean IL-15<\/span><span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p style=\"text-align: justify;\">IL-15 \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t cytokine quan tr\u1ecdng \u0111\u1ec3 duy tr\u00ec s\u1ef1 t\u0103ng sinh, tr\u01b0\u1edfng th\u00e0nh v\u00e0 ho\u1ea1t h\u00f3a ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o NK. D\u1ef1a tr\u00ean kh\u1ea3 n\u0103ng ch\u1ed1ng ung th\u01b0 v\u00e0 k\u00edch th\u00edch mi\u1ec5n d\u1ecbch, IL-15 t\u00e1i t\u1ed5 h\u1ee3p (rIL-15) \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn \u0111\u1ec3 th\u1eed nghi\u1ec7m trong c\u00e1c th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n I \u0111i\u1ec1u tr\u1ecb kh\u1ed1i u r\u1eafn kh\u00e1ng thu\u1ed1c th\u00f4ng qua \u0111\u01b0\u1eddng ti\u00eam t\u0129nh m\u1ea1ch ho\u1eb7c d\u01b0\u1edbi da. N\u1ebfu kh\u00f4ng c\u00f3 t\u00ecnh tr\u1ea1ng suy gi\u1ea3m lympho tr\u01b0\u1edbc \u0111\u00f3, li\u1ec7u ph\u00e1p \u0111\u01a1n tr\u1ecb rIL-15 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng m\u1ed9t c\u00e1ch an to\u00e0n v\u00e0 c\u00f3 th\u1ec3 g\u00e2y ra s\u1ef1 gia t\u0103ng \u0111\u00e1ng k\u1ec3 c\u00e1c t\u1ebf b\u00e0o NK v\u00e0 T CD8+ l\u01b0u h\u00e0nh; tuy nhi\u00ean, kh\u00f4ng quan s\u00e1t th\u1ea5y ph\u1ea3n \u1ee9ng kh\u00e1ch quan n\u00e0o. Nh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3i th\u00edch b\u1edfi th\u1ef1c t\u1ebf l\u00e0 b\u1ec7nh nh\u00e2n trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u00e3 \u0111\u01b0\u1ee3c x\u1eed l\u00fd tr\u01b0\u1edbc r\u1ea5t nhi\u1ec1u v\u00e0 h\u1ea7u h\u1ebft c\u00e1c t\u1ebf b\u00e0o NK \u0111\u01b0\u1ee3c khu\u1ebfch \u0111\u1ea1i \u0111\u1ec1u \u00edt g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o h\u01a1n . Do \u0111\u00f3, c\u1ea7n c\u00f3 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn hi\u1ec7u qu\u1ea3 \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng ho\u1ea1t t\u00ednh sinh h\u1ecdc v\u00e0 kh\u1ea3 n\u0103ng t\u1ed3n t\u1ea1i c\u1ee7a IL-15.<\/p>\n<p style=\"text-align: justify;\">IL-15 d\u1ecb h\u1ee3p t\u1eed (hetIL-15) bao g\u1ed3m IL-15 v\u00e0 IL-15R\u03b1, c\u00f3 th\u1eddi gian b\u00e1n h\u1ee7y k\u00e9o d\u00e0i v\u00e0 ho\u1ea1t t\u00ednh sinh h\u1ecdc v\u01b0\u1ee3t tr\u1ed9i, t\u1ea1o ra s\u1ef1 t\u1ed3n t\u1ea1i v\u00e0 m\u1edf r\u1ed9ng m\u1ea1nh h\u01a1n c\u1ee7a t\u1ebf b\u00e0o T NK v\u00e0 CD8+ so v\u1edbi rIL-15 . Trong tr\u01b0\u1eddng h\u1ee3p kh\u00f4ng c\u00f3 s\u1ef1 suy gi\u1ea3m lympho, vi\u1ec7c s\u1eed d\u1ee5ng hetIL-15 l\u00e0m t\u0103ng s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a t\u1ebf b\u00e0o T v\u00e0 t\u1ebf b\u00e0o NK v\u00e0o kh\u1ed1i u v\u00e0 c\u1ea3i thi\u1ec7n k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb \u1edf c\u00e1c m\u00f4 h\u00ecnh chu\u1ed9t kh\u1ed1i u r\u1eafn. M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p m\u1edbi kh\u00e1c c\u00f3 t\u00ean l\u00e0 N-803, m\u1ed9t si\u00eau ch\u1ea5t ch\u1ee7 v\u1eadn IL-15, bao g\u1ed3m m\u1ed9t \u0111\u1ed9t bi\u1ebfn IL-15 (N72D) li\u00ean k\u1ebft v\u1edbi protein h\u1ee3p nh\u1ea5t IL-15R\u03b1-IgG1-Fc. \u0110\u1ed9t bi\u1ebfn n\u00e0y l\u00e0m t\u0103ng \u00e1i l\u1ef1c li\u00ean k\u1ebft c\u1ee7a IL-15 v\u1edbi IL-15R\u03b2 v\u00e0 cung c\u1ea5p s\u1ef1 gia t\u0103ng ho\u1ea1t t\u00ednh sinh h\u1ecdc g\u1ea7n g\u1ea5p 30 l\u1ea7n so v\u1edbi IL-15. Ph\u1ea7n Fc k\u00e9o d\u00e0i th\u1eddi gian b\u00e1n h\u1ee7y v\u00e0 t\u1ea1o ra c\u00e1c t\u00e1c d\u1ee5ng mi\u1ec5n d\u1ecbch m\u1ea1nh h\u01a1n c\u1ee7a ch\u1ea5t ch\u1ee7 v\u1eadn trong c\u01a1 th\u1ec3 s\u1ed1ng . Li\u1ec7u ph\u00e1p N-803 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c l\u00e0m gi\u1ea3m s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a ung th\u01b0 v\u00e0 c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t \u1edf m\u1ed9t s\u1ed1 m\u00f4 h\u00ecnh chu\u1ed9t v\u00e0 c\u0169ng \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m trong nhi\u1ec1u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng . Trong th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n Ib, nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc ung th\u01b0 ph\u1ed5i kh\u00f4ng ph\u1ea3i t\u1ebf b\u00e0o nh\u1ecf (NSCLC) \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng N-803 k\u1ebft h\u1ee3p v\u1edbi ch\u1ea5t \u1ee9c ch\u1ebf \u0111i\u1ec3m ki\u1ec3m so\u00e1t mi\u1ec5n d\u1ecbch, cho th\u1ea5y t\u00ednh an to\u00e0n v\u00e0 ho\u1ea1t \u0111\u1ed9ng l\u00e2m s\u00e0ng \u0111\u1ea7y h\u1ee9a h\u1eb9n . M\u1ed9t th\u1eed nghi\u1ec7m kh\u00e1c cho th\u1ea5y N-803 k\u1ebft h\u1ee3p v\u1edbi mAb kh\u00e1ng CD20 l\u00e0m t\u0103ng \u0111\u1ed9c t\u00ednh t\u1ebf b\u00e0o NK khi xem x\u00e9t ADCC, d\u1eabn \u0111\u1ebfn t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t cao h\u01a1n . C\u00e1c th\u1eed nghi\u1ec7m n\u00e0y minh h\u1ecda cho hi\u1ec7u qu\u1ea3 c\u1ee7a vi\u1ec7c c\u1ea3i thi\u1ec7n ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o NK theo nh\u1eefng c\u00e1ch kh\u00e1c nhau.<\/p>\n<h2 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"Ket_luan\"><\/span>K\u1ebft lu\u1eadn<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p style=\"text-align: justify;\">T\u1ebf b\u00e0o NK, l\u00e0 t\u1ebf b\u00e0o \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch quan tr\u1ecdng, \u0111\u00f3ng vai tr\u00f2 thi\u1ebft y\u1ebfu trong gi\u00e1m s\u00e1t mi\u1ec5n d\u1ecbch ung th\u01b0. Tuy nhi\u00ean, ch\u1ee9c n\u0103ng v\u00e0 \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a t\u1ebf b\u00e0o NK b\u1ecb suy y\u1ebfu ho\u1eb7c bi\u1ebfn \u0111\u1ed5i trong qu\u00e1 tr\u00ecnh ti\u1ebfn tri\u1ec3n c\u1ee7a ung th\u01b0. T\u1ebf b\u00e0o NK b\u1ecb \u1ee9c ch\u1ebf ch\u1ee9c n\u0103ng trong TME do nhi\u1ec1u y\u1ebfu t\u1ed1 \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch, \u0111\u1eb7c bi\u1ec7t l\u00e0 TGF\u03b2. Do \u0111\u00f3, ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng ch\u1ee9c n\u0103ng ch\u1ed1ng ung th\u01b0 c\u1ee7a t\u1ebf b\u00e0o NK th\u00f4ng qua cytokine v\u00e0 kh\u00e1ng th\u1ec3 ch\u1eb7n. Nh\u1eefng h\u1ea1n ch\u1ebf v\u1ec1 m\u1eb7t k\u1ef9 thu\u1eadt c\u1ea3n tr\u1edf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o NK. Tuy nhi\u00ean, s\u1ef1 ti\u1ebfn b\u1ed9 v\u1ec1 c\u00f4ng ngh\u1ec7 \u0111\u00e3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i cho vi\u1ec7c t\u1ea1o ra, m\u1edf r\u1ed9ng v\u00e0 bi\u1ebfn \u0111\u1ed5i gen c\u1ee7a t\u1ebf b\u00e0o NK ngo\u00e0i c\u01a1 th\u1ec3 s\u1ed1ng, do \u0111\u00f3 t\u0103ng c\u01b0\u1eddng c\u00e1c \u0111\u1eb7c t\u00ednh ch\u1ed1ng ung th\u01b0 c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o NK. Hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o NK \u0111\u01a1n l\u1ebb ho\u1eb7c k\u1ebft h\u1ee3p v\u1edbi c\u00e1c t\u00e1c nh\u00e2n kh\u00e1c \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh r\u1ed9ng r\u00e3i trong nhi\u1ec1u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 c\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng kh\u00e1c \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh. Do \u0111\u00f3, c\u00f3 l\u00fd do \u0111\u1ec3 tin r\u1eb1ng li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o NK c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u1ea7y h\u1ee9a h\u1eb9n.<\/p>\n<p style=\"text-align: justify;\">\n","protected":false},"excerpt":{"rendered":"<p>T\u1ebf b\u00e0o NK r\u1ea5t c\u1ea7n thi\u1ebft cho kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch ch\u1ed1ng ung th\u01b0. S\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a nhi\u1ec1u y\u1ebfu t\u1ed1 \u1ee9c ch\u1ebf trong TME \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 \u1ee9c ch\u1ebf ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o NK. Ngo\u00e0i ra, c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m sinh h\u1ecdc c\u1ee7a t\u1ebf b\u00e0o NK v\u00e0 c\u00e1c k\u1ef9 thu\u1eadt s\u1eeda \u0111\u1ed5i [&#8230;]\n","protected":false},"author":2,"featured_media":2143,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2142"}],"collection":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2142"}],"version-history":[{"count":5,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2142\/revisions"}],"predecessor-version":[{"id":2292,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2142\/revisions\/2292"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/media\/2143"}],"wp:attachment":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}