{"id":2151,"date":"2025-07-08T12:53:40","date_gmt":"2025-07-08T12:53:40","guid":{"rendered":"https:\/\/lieuphapyhoctaitao.com\/?p=2151"},"modified":"2025-09-18T15:20:42","modified_gmt":"2025-09-18T15:20:42","slug":"%f0%9f%8e%af%f0%9f%8e%af%f0%9f%8e%af-ung-dung-lieu-phap-car-t-chimeric-antigen-receptor-t-cell-therapy-trong-dieu-tri-mien-dich","status":"publish","type":"post","link":"https:\/\/lieuphapyhoctaitao.com\/?p=2151","title":{"rendered":"\ud83c\udfaf\ud83c\udfaf\ud83c\udfaf \u1ee8NG D\u1ee4NG LI\u1ec6U PH\u00c1P\u00a0 CAR-T (Chimeric Antigen Receptor T-cell therapy) TRONG \u0110I\u1ec0U TR\u1eca MI\u1ec4N D\u1ecaCH\u00a0"},"content":{"rendered":"
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\ud83d\udd2c C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a CAR-T<\/span><\/div>\n
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Li\u1ec7u ph\u00e1p CAR-T s\u1eed d\u1ee5ng c\u00e1c t\u1ebf b\u00e0o T (m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u) \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb ch\u00ednh ng\u01b0\u1eddi b\u1ec7nh. C\u00e1c t\u1ebf b\u00e0o T n\u00e0y \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i gen trong ph\u00f2ng th\u00ed nghi\u1ec7m \u0111\u1ec3 t\u1ea1o ra th\u1ee5 th\u1ec3 kh\u00e1ng nguy\u00ean nh\u00e2n t\u1ea1o (CAR \u2013 Chimeric Antigen Receptor). Th\u1ee5 th\u1ec3 n\u00e0y gi\u00fap t\u1ebf b\u00e0o T nh\u1eadn di\u1ec7n v\u00e0 ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 mang kh\u00e1ng nguy\u00ean m\u1ee5c ti\u00eau.<\/span><\/div>\n
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\ud83e\uddeb C\u00e1c b\u1ec7nh l\u00fd \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng CAR-T<\/span><\/div>\n
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Ung th\u01b0 huy\u1ebft h\u1ecdc<\/span><\/div>\n
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CAR-T hi\u1ec7n \u0111\u01b0\u1ee3c \u1ee9ng d\u1ee5ng ch\u1ee7 y\u1ebfu trong c\u00e1c b\u1ec7nh l\u00fd huy\u1ebft h\u1ecdc \u00e1c t\u00ednh, \u0111\u1eb7c bi\u1ec7t l\u00e0:<\/span><\/div>\n
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B\u1ec7nh b\u1ea1ch c\u1ea7u lympho c\u1ea5p d\u00f2ng B (ALL) \u2013 \u0111\u1eb7c bi\u1ec7t \u1edf tr\u1ebb em v\u00e0 thanh thi\u1ebfu ni\u00ean.<\/span><\/div>\n
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Lymphoma t\u1ebf b\u00e0o B l\u1edbn lan t\u1ecfa (DLBCL).<\/span><\/div>\n
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U lympho kh\u00f4ng Hodgkin (NHL).<\/span><\/div>\n
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\u0110a u t\u1ee7y (Multiple Myeloma) \u2013 v\u1edbi \u0111\u00edch l\u00e0 BCMA (B-cell maturation antigen).<\/span><\/div>\n
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B\u1ea1ch c\u1ea7u lympho m\u00e3n t\u00ednh (CLL) \u2013 \u0111ang trong giai \u0111o\u1ea1n nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng.<\/span><\/div>\n
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\ud83c\udfaf H\u1ea7u h\u1ebft c\u00e1c li\u1ec7u ph\u00e1p hi\u1ec7n t\u1ea1i nh\u1eafm v\u00e0o kh\u00e1ng nguy\u00ean CD19 (tr\u00ean t\u1ebf b\u00e0o B) ho\u1eb7c BCMA (tr\u00ean t\u1ebf b\u00e0o plasma).<\/span><\/div>\n
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\ud83e\uddec Quy tr\u00ecnh \u0111i\u1ec1u tr\u1ecb CAR-T<\/span><\/div>\n
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Thu th\u1eadp t\u1ebf b\u00e0o T t\u1eeb b\u1ec7nh nh\u00e2n.<\/span><\/div>\n
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T\u00e1i l\u1eadp tr\u00ecnh gen \u0111\u1ec3 g\u1eafn th\u1ee5 th\u1ec3 CAR.<\/span><\/div>\n
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Nh\u00e2n b\u1ea3n t\u1ebf b\u00e0o CAR-T trong ph\u00f2ng th\u00ed nghi\u1ec7m.<\/span><\/div>\n
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Truy\u1ec1n tr\u1edf l\u1ea1i c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n sau khi h\u00f3a tr\u1ecb chu\u1ea9n b\u1ecb (lymphodepletion).<\/span><\/div>\n
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\ud83d\udd0d Tri\u1ec3n v\u1ecdng t\u01b0\u01a1ng lai<\/span><\/div>\n
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CAR-T \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ec3 m\u1edf r\u1ed9ng \u1ee9ng d\u1ee5ng sang:<\/span><\/div>\n
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Ung th\u01b0 r\u1eafn (nh\u01b0 ung th\u01b0 ph\u1ed5i, gan, v\u00fa…) \u2013 hi\u1ec7n c\u00f2n nhi\u1ec1u r\u00e0o c\u1ea3n.<\/span><\/div>\n
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B\u1ec7nh t\u1ef1 mi\u1ec5n (nh\u01b0 lupus ban \u0111\u1ecf h\u1ec7 th\u1ed1ng, vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p) \u2013 b\u01b0\u1edbc \u0111\u1ea7u c\u00f3 k\u1ebft qu\u1ea3 kh\u1ea3 quan.<\/span><\/div>\n
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Li\u1ec7u ph\u00e1p CAR-T “off-the-shelf” \u2013 s\u1eed d\u1ee5ng t\u1ebf b\u00e0o T t\u1eeb ng\u01b0\u1eddi hi\u1ebfn thay v\u00ec b\u1ec7nh nh\u00e2n, gi\u00fap gi\u1ea3m chi ph\u00ed v\u00e0 th\u1eddi gian.<\/span><\/div>\n
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\ud83d\udccc K\u1ebft lu\u1eadn<\/span><\/div>\n
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Li\u1ec7u ph\u00e1p CAR-T l\u00e0 b\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh ung th\u01b0 huy\u1ebft h\u1ecdc, \u0111\u1eb7c bi\u1ec7t \u1edf c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u00e1ng tr\u1ecb. Trong t\u01b0\u01a1ng lai, v\u1edbi c\u00e1c ti\u1ebfn b\u1ed9 c\u00f4ng ngh\u1ec7 sinh h\u1ecdc, CAR-T c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh li\u1ec7u ph\u00e1p ph\u1ed5 bi\u1ebfn v\u00e0 an to\u00e0n h\u01a1n.<\/span><\/div>\n","protected":false},"excerpt":{"rendered":"

\ud83d\udd2c C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a CAR-T Li\u1ec7u ph\u00e1p CAR-T s\u1eed d\u1ee5ng c\u00e1c t\u1ebf b\u00e0o T (m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u) \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb ch\u00ednh ng\u01b0\u1eddi b\u1ec7nh. C\u00e1c t\u1ebf b\u00e0o T n\u00e0y \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i gen trong ph\u00f2ng th\u00ed nghi\u1ec7m \u0111\u1ec3 t\u1ea1o ra th\u1ee5 th\u1ec3 kh\u00e1ng nguy\u00ean nh\u00e2n t\u1ea1o (CAR \u2013 Chimeric Antigen Receptor). […]\n","protected":false},"author":2,"featured_media":2152,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4,1,9,11],"tags":[],"_links":{"self":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2151"}],"collection":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2151"}],"version-history":[{"count":2,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2151\/revisions"}],"predecessor-version":[{"id":2291,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2151\/revisions\/2291"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/media\/2152"}],"wp:attachment":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2151"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2151"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}