{"id":2203,"date":"2025-09-08T01:55:32","date_gmt":"2025-09-08T01:55:32","guid":{"rendered":"https:\/\/lieuphapyhoctaitao.com\/?p=2203"},"modified":"2025-09-18T15:16:56","modified_gmt":"2025-09-18T15:16:56","slug":"%f0%9f%8e%af%f0%9f%8e%af%f0%9f%8e%afnad-xu-huong-chong-lao-hoa-moi-trong-y-hoc-tai-sinh","status":"publish","type":"post","link":"https:\/\/lieuphapyhoctaitao.com\/?p=2203","title":{"rendered":"\ud83c\udfaf\ud83c\udfaf\ud83c\udfafNAD+ XU H\u01af\u1edaNG CH\u1ed0NG L\u00c3O H\u00d3A M\u1edaI TRONG Y H\u1eccC T\u00c1I SINH"},"content":{"rendered":"<p style=\"text-align: justify;\">NAD\u207a l\u00e0 \u0111\u1ed3ng y\u1ebfu t\u1ed1 trung t\u00e2m c\u1ee7a chuy\u1ec3n ho\u00e1 v\u00e0 l\u00e0 \u201cnhi\u00ean li\u1ec7u\u201d cho c\u00e1c enzyme s\u1eeda ch\u1eefa DNA (PARP), kh\u1eed acetyl (sirtuin) v\u00e0 t\u00edn hi\u1ec7u mi\u1ec5n d\u1ecbch (CD38). M\u1ee9c NAD\u207a gi\u1ea3m theo tu\u1ed5i v\u00e0 trong nhi\u1ec1u b\u1ec7nh m\u1ea1n t\u00ednh; t\u0103ng NAD\u207a b\u1eb1ng ti\u1ec1n ch\u1ea5t (NR, NMN, niacin\/nicotinamide) cho th\u1ea5y nhi\u1ec1u h\u1ee9a h\u1eb9n \u1edf m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt v\u00e0 m\u1ed9t s\u1ed1 t\u00edn hi\u1ec7u ban \u0111\u1ea7u \u1edf ng\u01b0\u1eddi.<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" class=\"size-medium wp-image-2209 aligncenter\" src=\"https:\/\/lieuphapyhoctaitao.com\/wp-content\/uploads\/2025\/09\/nad-3d-285x300.png\" alt=\"\" width=\"285\" height=\"300\" srcset=\"https:\/\/lieuphapyhoctaitao.com\/wp-content\/uploads\/2025\/09\/nad-3d-285x300.png 285w, https:\/\/lieuphapyhoctaitao.com\/wp-content\/uploads\/2025\/09\/nad-3d.png 700w\" sizes=\"(max-width: 285px) 100vw, 285px\" \/><\/p>\n<p style=\"text-align: justify;\"><strong>1) NAD\u207a l\u00e0 g\u00ec v\u00e0 v\u00ec sao quan tr\u1ecdng trong t\u00e1i sinh \u2013 ch\u1ed1ng l\u00e3o h\u00f3a?<\/strong><\/p>\n<p style=\"text-align: justify;\">NAD\u207a (nicotinamide adenine dinucleotide) kh\u00f4ng ch\u1ec9 tham gia ph\u1ea3n \u1ee9ng oxy-ho\u00e1 kh\u1eed m\u00e0 c\u00f2n l\u00e0 c\u01a1 ch\u1ea5t c\u1ee7a <strong>sirtuin<\/strong> (\u0111i\u1ec1u ho\u00e0 epigen\/ti th\u1ec3), <strong>PARP<\/strong> (s\u1eeda ch\u1eefa DNA), <strong>CD38<\/strong> (t\u00edn hi\u1ec7u canxi\/mi\u1ec5n d\u1ecbch)\u2026 Suy gi\u1ea3m NAD\u207a li\u00ean quan r\u1ed1i lo\u1ea1n chuy\u1ec3n ho\u00e1, suy gi\u1ea3m ch\u1ee9c n\u0103ng m\u00f4, vi\u00eam l\u00e3o ho\u00e1 v\u00e0 b\u1ec7nh tim m\u1ea1ch \u2013 th\u1ea7n kinh.<\/p>\n<p style=\"text-align: justify;\"><strong>V\u00ec sao NAD\u207a gi\u1ea3m theo tu\u1ed5i?<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li><strong>T\u0103ng ti\u00eau th\u1ee5<\/strong>: ho\u1ea1t ho\u00e1 <strong>PARP<\/strong> b\u1edfi t\u1ed5n th\u01b0\u01a1ng DNA v\u00e0 t\u0103ng <strong>CD38<\/strong> \u1edf m\u00f4 l\u00e3o h\u00f3a \u201c\u0111\u1ed1t\u201d NAD\u207a nhanh h\u01a1n.<\/li>\n<li><strong>Gi\u1ea3m t\u00e1i sinh<\/strong>: suy gi\u1ea3m tr\u1ee5c <strong>salvage NAMPT<\/strong> v\u00e0 l\u1ec7ch c\u00e2n b\u1eb1ng gi\u1eefa c\u00e1c ng\u0103n t\u1ebf b\u00e0o.<br \/>\nC\u00e1c c\u01a1 ch\u1ebf n\u00e0y khi\u1ebfn d\u1ef1 tr\u1eef NAD\u207a gi\u1ea3m d\u1ea7n theo tu\u1ed5i v\u00e0 stress m\u1ea1n t\u00ednh.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>2) \u0110\u01b0\u1eddng sinh t\u1ed5ng h\u1ee3p &amp; c\u00e1c \u201c\u0111\u00f2n b\u1ea9y\u201d t\u0103ng NAD\u207a<\/strong><\/p>\n<p style=\"text-align: justify;\">C\u01a1 th\u1ec3 t\u1ea1o NAD\u207a qua ba nh\u00e1nh ch\u00ednh: <strong>salvage<\/strong> (t\u1eeb nicotinamide\/NAM do NAMPT x\u00fac t\u00e1c), <strong>Preiss\u2013Handler<\/strong> (t\u1eeb niacin\/NA) v\u00e0 <strong>de novo<\/strong> (t\u1eeb tryptophan). T\u0103ng NAD\u207a c\u00f3 th\u1ec3 b\u1eb1ng <strong>thay \u0111\u1ed5i l\u1ed1i s\u1ed1ng<\/strong> (t\u1eadp luy\u1ec7n, h\u1ea1n ch\u1ebf n\u0103ng l\u01b0\u1ee3ng, gi\u1ea5c ng\u1ee7) \u2013 c\u00e1c y\u1ebfu t\u1ed1 n\u00e0y th\u01b0\u1eddng t\u0103ng NAMPT v\u00e0 c\u1ea3i thi\u1ec7n c\u00e2n b\u1eb1ng NAD\u207a \u2013 ho\u1eb7c <strong>b\u1ed5 sung ti\u1ec1n ch\u1ea5t<\/strong> nh\u01b0 <strong>NR<\/strong> (nicotinamide riboside), <strong>NMN<\/strong> (nicotinamide mononucleotide), <strong>NAM\/NA<\/strong>. L\u01b0u \u00fd NAM li\u1ec1u r\u1ea5t cao c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf sirtuin in vitro; NA c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ecf b\u1eebng.<\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><strong>3) Ti\u1ec1n ch\u1ea5t NAD\u207a: NR, NMN, NAM\/NA &amp; NAD\u207a \u201ctruy\u1ec1n t\u0129nh m\u1ea1ch\u201d<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Nicotinamide riboside (NR)<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>T\u0103ng NAD\u207a m\u00e1u\/h\u1ed3ng c\u1ea7u r\u00f5 r\u1ec7t \u1edf ng\u01b0\u1eddi v\u00e0 <strong>an to\u00e0n li\u1ec1u cao<\/strong> trong ng\u1eafn h\u1ea1n; c\u00e1c ch\u1ec9 d\u1ea5u l\u00e2m s\u00e0ng c\u1ea3i thi\u1ec7n tu\u1ef3 qu\u1ea7n th\u1ec3.<\/li>\n<li><strong>K\u1ebft qu\u1ea3 ch\u1ee9c n\u0103ng<\/strong>: th\u1eed nghi\u1ec7m ng\u1eabu nhi\u00ean \u1edf <strong>b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch chi d\u01b0\u1edbi (PAD)<\/strong> cho th\u1ea5y NR c\u1ea3i thi\u1ec7n qu\u00e3ng \u0111\u01b0\u1eddng \u0111i b\u1ed9 6 ph\u00fat (hi\u1ec7u qu\u1ea3 khi tu\u00e2n th\u1ee7 \u226575%); \u1edf ng\u01b0\u1eddi b\u00e9o ph\u00ec\/\u0111\u1ec1 kh\u00e1ng insulin, NR <strong>kh\u00f4ng c\u1ea3i thi\u1ec7n<\/strong> nh\u1ea1y insulin hay ch\u1ee9c n\u0103ng ty th\u1ec3 c\u01a1.<\/li>\n<li><strong>Th\u1ea7n kinh h\u1ecdc<\/strong>: nghi\u00ean c\u1ee9u <strong>NADPARK<\/strong> (Parkinson) ghi nh\u1eadn NR dung n\u1ea1p t\u1ed1t v\u00e0 t\u0103ng NAD\u207a n\u00e3o \u0111o b\u1eb1ng ^31P-MRS, l\u00e0 b\u1eb1ng ch\u1ee9ng d\u01b0\u1ee3c l\u00fd quan tr\u1ecdng, d\u00f9 hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng c\u1ea7n nghi\u00ean c\u1ee9u l\u1edbn h\u01a1n.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>Nicotinamide mononucleotide (NMN)<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li>Th\u1eed nghi\u1ec7m b\u1eaft ch\u00e9o m\u00f9 \u0111\u00f4i \u1edf ph\u1ee5 n\u1eef qu\u00e1 c\u00e2n\/ti\u1ec1n \u0110T\u0110: <strong>NMN 250 mg\/ng\u00e0y<\/strong> c\u1ea3i thi\u1ec7n x\u1eed l\u00fd glucose c\u01a1 x\u01b0\u01a1ng; c\u00e1c RCT nh\u1ecf kh\u00e1c b\u00e1o c\u00e1o t\u00edn hi\u1ec7u thu\u1eadn \u1edf lipid v\u00e0 s\u1ee9c b\u1ec1n nh\u01b0ng k\u00edch th\u01b0\u1edbc m\u1eabu nh\u1ecf.<\/li>\n<li><strong>2025 (Igarashi)<\/strong>: vi\u00ean <strong>NMN 300 mg\/ng\u00e0y<\/strong> c\u1ea3i thi\u1ec7n th\u00e0nh t\u00edch ch\u1ea1y \u1edf v\u1eadn \u0111\u1ed9ng vi\u00ean, g\u1ee3i \u00fd l\u1ee3i \u00edch tr\u00ean hi\u1ec7u n\u0103ng c\u01a1 \u2013 c\u1ea7n x\u00e1c nh\u1eadn th\u00eam.<\/li>\n<li><strong>H\u1ea5p thu \u0111ang tranh lu\u1eadn<\/strong>: c\u00f3 b\u00e1o c\u00e1o v\u1ec1 <strong>v\u1eadn chuy\u1ec3n NMN qua SLC12A8<\/strong> \u1edf ru\u1ed9t chu\u1ed9t, song c\u00e1c nh\u00f3m kh\u00e1c n\u00eau <strong>b\u1eb1ng ch\u1ee9ng tr\u00e1i chi\u1ec1u<\/strong>; nhi\u1ec1u d\u1eef li\u1ec7u g\u1ee3i \u00fd <strong>NR\/NMN b\u1ecb chuy\u1ec3n ho\u00e1 tr\u01b0\u1edbc khi v\u00e0o t\u1ebf b\u00e0o<\/strong> (\u0111\u1eb7c bi\u1ec7t \u1edf \u0111\u1ed9ng v\u1eadt g\u1eb7m nh\u1ea5m).<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>NAM\/NA (vitamin B3 c\u1ed5 \u0111i\u1ec3n)<\/strong><\/p>\n<p style=\"text-align: justify;\">Niacin (NA) ch\u1eafc ch\u1eafn n\u00e2ng NAD\u207a qua \u0111\u01b0\u1eddng Preiss\u2013Handler nh\u01b0ng d\u1ec5 <strong>\u0111\u1ecf b\u1eebng<\/strong>; nicotinamide (NAM) \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 h\u01a1n, tuy nhi\u00ean <strong>li\u1ec1u r\u1ea5t cao<\/strong> c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf ho\u1ea1t t\u00ednh sirtuin trong \u1ed1ng nghi\u1ec7m \u2013 \u00fd ngh\u0129a l\u00e2m s\u00e0ng c\u00f2n \u0111ang l\u00e0m r\u00f5.<\/p>\n<p style=\"text-align: justify;\"><strong>4) B\u1eb1ng ch\u1ee9ng ti\u1ec1n l\u00e2m s\u00e0ng cho t\u00e1i sinh\/t\u1ebf b\u00e0o g\u1ed1c<\/strong><\/p>\n<p style=\"text-align: justify;\">Tr\u00ean chu\u1ed9t gi\u00e0, <strong>b\u1ed5 sung NR\/NMN<\/strong> ph\u1ee5c h\u1ed3i ch\u1ee9c n\u0103ng t\u1ebf b\u00e0o g\u1ed1c c\u01a1 v\u00e0 m\u00e1u, c\u1ea3i thi\u1ec7n t\u00e1i sinh m\u00f4 v\u00e0 nhi\u1ec1u tr\u1ee5c sinh l\u00fd l\u00e3o h\u00f3a; sirtuin\/NAD\u207a c\u00f2n li\u00ean quan duy tr\u00ec <strong>\u201cstemness\u201d<\/strong> v\u00e0 <strong>chuy\u1ec3n ho\u00e1 ty th\u1ec3<\/strong> c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c. \u1ede th\u1ea7n kinh, tr\u1ee5c <strong>SARM1\u2013NAD\u207a<\/strong> ki\u1ec3m so\u00e1t tho\u00e1i ho\u00e1 s\u1ee3i tr\u1ee5c; \u1ee9c ch\u1ebf SARM1 \u0111ang \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n ti\u1ec1n l\u00e2m s\u00e0ng\/\u0111\u1ea7u l\u00e2m s\u00e0ng cho b\u1ec7nh th\u1ea7n kinh. (L\u01b0u \u00fd: k\u1ebft qu\u1ea3 tr\u00ean \u0111\u1ed9ng v\u1eadt kh\u00f4ng \u0111\u1ed3ng ngh\u0129a hi\u1ec7u qu\u1ea3 ng\u01b0\u1eddi.)<\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><img loading=\"lazy\" class=\"size-medium wp-image-2210 aligncenter\" src=\"https:\/\/lieuphapyhoctaitao.com\/wp-content\/uploads\/2025\/09\/NAD-Blog_Infographic-04-300x173.webp\" alt=\"\" width=\"300\" height=\"173\" srcset=\"https:\/\/lieuphapyhoctaitao.com\/wp-content\/uploads\/2025\/09\/NAD-Blog_Infographic-04-300x173.webp 300w, https:\/\/lieuphapyhoctaitao.com\/wp-content\/uploads\/2025\/09\/NAD-Blog_Infographic-04-1024x591.webp 1024w, https:\/\/lieuphapyhoctaitao.com\/wp-content\/uploads\/2025\/09\/NAD-Blog_Infographic-04-768x443.webp 768w, https:\/\/lieuphapyhoctaitao.com\/wp-content\/uploads\/2025\/09\/NAD-Blog_Infographic-04.webp 1040w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p style=\"text-align: justify;\"><strong>5) An to\u00e0n, r\u1ee7i ro v\u00e0 v\u00f9ng x\u00e1m<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li><strong>NR<\/strong>: \u0111a s\u1ed1 RCT b\u00e1o c\u00e1o <strong>dung n\u1ea1p t\u1ed1t<\/strong> (\u0111\u00f4i khi ti\u00eau ho\u00e1 nh\u1eb9); th\u1eed nghi\u1ec7m <strong>NR-SAFE<\/strong> cho th\u1ea5y li\u1ec1u t\u1edbi 3 g\/ng\u00e0y trong 8 tu\u1ea7n an to\u00e0n \u1edf ng\u01b0\u1eddi kho\u1ebb m\u1ea1nh, nh\u01b0ng c\u00f3 <strong>t\u0103ng nh\u1eb9 homocysteine<\/strong> \u2013 h\u00e0m \u00fd theo d\u00f5i chuy\u1ec3n ho\u00e1 methyl.<\/li>\n<li><strong>NMN<\/strong>: nh\u00ecn chung dung n\u1ea1p t\u1ed1t trong c\u00e1c RCT nh\u1ecf (250\u2013600 mg\/ng\u00e0y, 6\u201312 tu\u1ea7n); c\u1ea7n d\u1eef li\u1ec7u d\u00e0i h\u1ea1n v\u00e0 \u1edf b\u1ec7nh nh\u00e2n.<\/li>\n<li><strong>Ung th\u01b0<\/strong>: b\u1ee9c tranh <strong>ph\u1ee9c t\u1ea1p<\/strong>. M\u1ed9t s\u1ed1 t\u1ed5ng quan c\u1ea3nh b\u00e1o v\u1ec1 m\u1eb7t l\u00fd thuy\u1ebft vi\u1ec7c <strong>duy tr\u00ec NAD\u207a cao<\/strong> c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 chuy\u1ec3n ho\u00e1\/ s\u1eeda ch\u1eefa DNA c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0; nghi\u00ean c\u1ee9u h\u00ecnh \u1ea3nh \u1edf <strong>\u0111\u1ed9ng v\u1eadt<\/strong> g\u1ee3i \u00fd m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa <strong>NR<\/strong> v\u00e0 <strong>di c\u0103n n\u00e3o<\/strong> trong m\u00f4 h\u00ecnh \u0111\u1eb7c hi\u1ec7u \u2013 <strong>ch\u01b0a c\u00f3 b\u1eb1ng ch\u1ee9ng \u1edf ng\u01b0\u1eddi<\/strong>. \u0110\u00e1ng ch\u00fa \u00fd, m\u1eb7t \u0111\u1ed1i ngh\u1ecbch l\u00e0 <strong>\u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p NAD\u207a<\/strong> (NAMPT inhibitors) \u0111ang \u0111\u01b0\u1ee3c khai th\u00e1c nh\u01b0 li\u1ec7u ph\u00e1p ung th\u01b0. V\u00ec v\u1eady, <strong>b\u1ec7nh nh\u00e2n ung th\u01b0\/ti\u1ec1n s\u1eed ung th\u01b0<\/strong> n\u00ean h\u1ecfi \u00fd ki\u1ebfn b\u00e1c s\u0129 tr\u01b0\u1edbc khi d\u00f9ng \u201cbooster\u201d NAD\u207a.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>6) T\u00ecnh tr\u1ea1ng ph\u00e1p l\u00fd &amp; qu\u1ea3n l\u00fd ch\u1ea5t l\u01b0\u1ee3ng<\/strong><\/p>\n<ul style=\"text-align: justify;\">\n<li><strong>M\u1ef9 (2025):<\/strong> <strong>NMN<\/strong> hi\u1ec7n n\u1eb1m trong <strong>Danh m\u1ee5c Th\u00e0nh ph\u1ea7n<\/strong> c\u1ee7a FDA \u1edf nh\u00f3m <strong>\u201cb\u1ecb lo\u1ea1i kh\u1ecfi \u0111\u1ecbnh ngh\u0129a th\u1ef1c ph\u1ea9m b\u1ed5 sung\u201d<\/strong> do \u0111ang\/\u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n nh\u01b0 <strong>thu\u1ed1c<\/strong> (c\u1eadp nh\u1eadt 23\/05\/2025). Ngh\u0129a l\u00e0 NMN <strong>kh\u00f4ng h\u1ee3p l\u1ec7<\/strong> l\u00e0m th\u00e0nh ph\u1ea7n th\u1ef1c ph\u1ea9m b\u1ed5 sung \u1edf M\u1ef9 (tu\u00e2n th\u1ee7 th\u1ef1c thi tu\u1ef3 th\u1eddi \u0111i\u1ec3m).<\/li>\n<li><strong>NR<\/strong>: \u0111\u00e3 c\u00f3 <strong>th\u00f4ng b\u00e1o th\u00e0nh ph\u1ea7n m\u1edbi (NDI)<\/strong> \u0111\u01b0\u1ee3c ch\u1ea5p thu\u1eadn v\u00e0 <strong>GRAS<\/strong> cho m\u1ed9t s\u1ed1 d\u1ea1ng mu\u1ed1i (v\u00ed d\u1ee5 NR chloride), cho ph\u00e9p l\u01b0u h\u00e0nh th\u1ef1c ph\u1ea9m b\u1ed5 sung <strong>khi \u0111\u00e1p \u1ee9ng \u0111i\u1ec1u ki\u1ec7n an to\u00e0n\/ghi nh\u00e3n<\/strong>.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>L\u01b0u \u00fd:<\/strong> Khung ph\u00e1p l\u00fd kh\u00e1c nhau gi\u1eefa c\u00e1c qu\u1ed1c gia; lu\u00f4n ki\u1ec3m tra quy \u0111\u1ecbnh \u0111\u1ecba ph\u01b0\u01a1ng c\u1ee7a b\u1ea1n.<\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><strong>7) \u1ee8ng d\u1ee5ng th\u1ef1c ti\u1ec5n trong y h\u1ecdc t\u00e1i sinh (g\u1ee3i \u00fd \u0111\u1ecbnh h\u01b0\u1edbng)<\/strong><\/p>\n<ol>\n<li style=\"text-align: justify;\"><strong>Nh\u1eafm m\u1ee5c ti\u00eau m\u00f4\/\u0111\u1ed1i t\u01b0\u1ee3ng ph\u00f9 h\u1ee3p:<\/strong> B\u1eb1ng ch\u1ee9ng ng\u01b0\u1eddi hi\u1ec7n h\u1ee9a h\u1eb9n nh\u1ea5t \u1edf <strong>PAD<\/strong> (c\u1ea3i thi\u1ec7n \u0111i b\u1ed9), m\u1ed9t s\u1ed1 ch\u1ec9 d\u1ea5u chuy\u1ec3n ho\u00e1 v\u00e0 NAD\u207a n\u00e3o; ch\u01b0a c\u00f3 k\u1ebft qu\u1ea3 r\u00f5 r\u00e0ng cho \u201cch\u1ed1ng l\u00e3o h\u00f3a to\u00e0n th\u00e2n\u201d.<\/li>\n<li style=\"text-align: justify;\"><strong>K\u1ebf ho\u1ea1ch t\u0103ng NAD\u207a b\u1eadc thang:<\/strong> \u01b0u ti\u00ean <strong>can thi\u1ec7p l\u1ed1i s\u1ed1ng<\/strong> (t\u1eadp s\u1ee9c b\u1ec1n + s\u1ee9c m\u1ea1nh, ng\u1ee7, dinh d\u01b0\u1ee1ng gi\u00e0u niacin\/tryptophan), sau \u0111\u00f3 <strong>c\u00e2n nh\u1eafc ti\u1ec1n ch\u1ea5t<\/strong> (NR ho\u1eb7c \u2013 \u1edf n\u01a1i h\u1ee3p ph\u00e1p \u2013 NMN) d\u1ef1a tr\u00ean m\u1ee5c ti\u00eau v\u00e0 t\u00ecnh tr\u1ea1ng b\u1ec7nh.<\/li>\n<li style=\"text-align: justify;\"><strong>Li\u1ec1u tham kh\u1ea3o t\u1eeb RCT:<\/strong>\n<ul>\n<li><strong>NR:<\/strong> 1000\u20132000 mg\/ng\u00e0y (6 th\u00e1ng trong PAD; 8\u201312 tu\u1ea7n \u1edf c\u00e1c qu\u1ea7n th\u1ec3 kh\u00e1c).<\/li>\n<li><strong>NMN:<\/strong> 250\u2013600 mg\/ng\u00e0y (6\u201312 tu\u1ea7n) trong c\u00e1c RCT nh\u1ecf\/crossover.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Theo d\u00f5i an to\u00e0n:<\/strong> ti\u00eau ho\u00e1, <strong>homocysteine<\/strong> (khi d\u00f9ng NR li\u1ec1u cao), t\u01b0\u01a1ng t\u00e1c thu\u1ed1c (\u0111\u1eb7c bi\u1ec7t b\u1ec7nh nh\u00e2n tim m\u1ea1ch\/ung th\u01b0). <strong>Tr\u00e1nh truy\u1ec1n\/ti\u00eam<\/strong> NAD\u207a ngo\u00e0i c\u01a1 s\u1edf y t\u1ebf \u0111\u1ea1t chu\u1ea9n.<strong>8) Nh\u1eefng c\u00e2u h\u1ecfi m\u1edf cho 2025+<\/strong>\n<ul style=\"text-align: justify;\">\n<li><strong>\u0110\u00edch m\u00f4 &amp; \u0111\u1ecbnh li\u1ec1u c\u00e1 th\u1ec3 ho\u00e1:<\/strong> v\u00ec t\u0103ng NAD\u207a ngo\u1ea1i vi kh\u00f4ng lu\u00f4n chuy\u1ec3n th\u00e0nh l\u1ee3i \u00edch ch\u1ee9c n\u0103ng m\u00f4 \u0111\u00edch.<\/li>\n<li><strong>D\u00e0i h\u1ea1n &amp; \u201chard outcomes\u201d:<\/strong> c\u1ea7n RCT \u0111\u1ee7 l\u1edbn theo d\u00f5i t\u1eed vong, nh\u1eadp vi\u1ec7n, sa s\u00fat tr\u00ed tu\u1ec7\u2026 thay v\u00ec ch\u1ec9 d\u1ea5u trung gian.<\/li>\n<li><strong>Sinh h\u1ecdc h\u1ea5p thu ng\u01b0\u1eddi:<\/strong> m\u1ee9c \u0111\u1ed9 <strong>v\u1eadn chuy\u1ec3n tr\u1ef1c ti\u1ebfp NMN<\/strong> \u1edf ng\u01b0\u1eddi v\u1eabn g\u00e2y tranh lu\u1eadn; d\u1eef li\u1ec7u m\u1edbi tr\u00ean \u0111\u1ed9ng v\u1eadt cho th\u1ea5y NR\/NMN b\u1ecb <strong>chuy\u1ec3n ho\u00e1 tr\u01b0\u1edbc khi n\u1ed9i nh\u1eadp<\/strong>.<\/li>\n<li><strong>An to\u00e0n ung th\u01b0:<\/strong> c\u00e2n b\u1eb1ng gi\u1eefa l\u1ee3i \u00edch ph\u1ee5c h\u1ed3i m\u00f4 v\u00e0 nguy c\u01a1 ti\u1ec1m t\u00e0ng trong m\u1ed9t s\u1ed1 b\u1ed1i c\u1ea3nh ung th\u01b0.<\/li>\n<\/ul>\n<p style=\"text-align: justify;\"><strong>K\u1ebft lu\u1eadn<\/strong><\/p>\n<p style=\"text-align: justify;\">N\u00e2ng NAD\u207a l\u00e0 <strong>h\u01b0\u1edbng \u0111i sinh h\u1ecdc h\u1ee3p l\u00fd<\/strong> \u0111\u1ec3 \u201cl\u00e0m tr\u1ebb\u201d ch\u1ee9c n\u0103ng t\u1ebf b\u00e0o, h\u1ed7 tr\u1ee3 s\u1eeda ch\u1eefa m\u00f4 v\u00e0 c\u00f3 ch\u1ed7 \u0111\u1ee9ng ti\u1ec1m n\u0103ng trong <strong>y h\u1ecdc t\u00e1i sinh<\/strong>. L\u1ef1a ch\u1ecdn s\u1ea3n ph\u1ea9m\/chi\u1ebfn l\u01b0\u1ee3c n\u00ean <strong>c\u00e1 th\u1ec3 ho\u00e1, tu\u00e2n th\u1ee7 ph\u00e1p l\u00fd<\/strong>, v\u00e0 \u0111\u1eb7t trong ch\u01b0\u01a1ng tr\u00ecnh ch\u0103m s\u00f3c do b\u00e1c s\u0129 theo d\u00f5i.<\/p>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>NAD\u207a l\u00e0 \u0111\u1ed3ng y\u1ebfu t\u1ed1 trung t\u00e2m c\u1ee7a chuy\u1ec3n ho\u00e1 v\u00e0 l\u00e0 \u201cnhi\u00ean li\u1ec7u\u201d cho c\u00e1c enzyme s\u1eeda ch\u1eefa DNA (PARP), kh\u1eed acetyl (sirtuin) v\u00e0 t\u00edn hi\u1ec7u mi\u1ec5n d\u1ecbch (CD38). M\u1ee9c NAD\u207a gi\u1ea3m theo tu\u1ed5i v\u00e0 trong nhi\u1ec1u b\u1ec7nh m\u1ea1n t\u00ednh; t\u0103ng NAD\u207a b\u1eb1ng ti\u1ec1n ch\u1ea5t (NR, NMN, niacin\/nicotinamide) cho th\u1ea5y nhi\u1ec1u h\u1ee9a h\u1eb9n \u1edf [&#8230;]\n","protected":false},"author":2,"featured_media":2204,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[9,11],"tags":[],"_links":{"self":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2203"}],"collection":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2203"}],"version-history":[{"count":6,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2203\/revisions"}],"predecessor-version":[{"id":2285,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2203\/revisions\/2285"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/media\/2204"}],"wp:attachment":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2203"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2203"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2203"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}