{"id":2270,"date":"2025-09-17T07:59:46","date_gmt":"2025-09-17T07:59:46","guid":{"rendered":"https:\/\/lieuphapyhoctaitao.com\/?p=2270"},"modified":"2025-09-18T15:14:14","modified_gmt":"2025-09-18T15:14:14","slug":"%f0%9f%8e%af%f0%9f%8e%af%f0%9f%8e%afung-dung-lieu-phap-car-t-trong-dieu-tri-u-lympho-khong-hodgkin-va-da-u-tuy","status":"publish","type":"post","link":"https:\/\/lieuphapyhoctaitao.com\/?p=2270","title":{"rendered":"\ud83c\udfaf\ud83c\udfaf\ud83c\udfaf\u1ee8ng d\u1ee5ng li\u1ec7u ph\u00e1p CAR-T trong \u0111i\u1ec1u tr\u1ecb u lympho kh\u00f4ng Hodgkin v\u00e0 \u0111a u t\u1ee7y"},"content":{"rendered":"<h2 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"Gioi_thieu\"><\/span><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong>Gi\u1edbi thi\u1ec7u<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u00d4\u0323I DUNG:<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2270\/#Gioi_thieu\" >Gi\u1edbi thi\u1ec7u<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2270\/#%F0%9F%94%AC_Co_che_hoat_dong\" >\ud83d\udd2c C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2270\/#Ung_dung_lam_sang_tai_cac_quoc_gia_phat_trien\" >\u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng t\u1ea1i c\u00e1c qu\u1ed1c gia ph\u00e1t tri\u1ec3n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2270\/#Bang_chung_nghien_cuu_lam_sang\" >B\u1eb1ng ch\u1ee9ng nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2270\/#Uu_diem_cua_CAR-T_trong_u_lympho_khong_Hodgkin_da_u_tuy\" >\u01afu \u0111i\u1ec3m c\u1ee7a CAR-T trong u lympho kh\u00f4ng Hodgkin &amp; \u0111a u t\u1ee7y<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2270\/#Tai_lieu_tham_khao_uy_tin\" >T\u00e0i li\u1ec7u tham kh\u1ea3o uy t\u00edn<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2270\/#Ket_Luan\" >K\u1ebft Lu\u1eadn<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2270\/#Cau_hoi_thuong_gap_ve_lieu_phap_CAR-T_trong_u_lympho_khong_Hodgkin_va_da_u_tuy\" >C\u00e2u h\u1ecfi th\u01b0\u1eddng g\u1eb7p v\u1ec1 li\u1ec7u ph\u00e1p CAR-T trong u lympho kh\u00f4ng Hodgkin v\u00e0 \u0111a u t\u1ee7y<\/a><\/li><\/ul><\/nav><\/div>\n\n<p style=\"text-align: justify;\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong>Li\u1ec7u ph\u00e1p CAR-T (Chimeric Antigen Receptor T-cell therapy)<\/strong> \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t trong nh\u1eefng b\u01b0\u1edbc ngo\u1eb7t c\u1ee7a y h\u1ecdc hi\u1ec7n \u0111\u1ea1i trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 huy\u1ebft h\u1ecdc. Thay v\u00ec h\u00f3a tr\u1ecb hay x\u1ea1 tr\u1ecb truy\u1ec1n th\u1ed1ng, CAR-T t\u1eadn d\u1ee5ng ch\u00ednh t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n, t\u00e1i l\u1eadp tr\u00ecnh \u0111\u1ec3 nh\u1eadn di\u1ec7n v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">Trong nhi\u1ec1u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng qu\u1ed1c t\u1ebf, CAR-T \u0111\u00e3 ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 v\u01b0\u1ee3t tr\u1ed9i \u1edf b\u1ec7nh nh\u00e2n <strong>u lympho kh\u00f4ng Hodgkin (NHL)<\/strong> v\u00e0 <strong>\u0111a u t\u1ee7y (Multiple Myeloma)<\/strong> \u2013 nh\u1eefng b\u1ec7nh l\u00fd v\u1ed1n kh\u00f3 \u0111i\u1ec1u tr\u1ecb khi \u0111\u00e3 kh\u00e1ng l\u1ea1i c\u00e1c ph\u00e1c \u0111\u1ed3 chu\u1ea9n.<\/span><\/p>\n<h2 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"%F0%9F%94%AC_Co_che_hoat_dong\"><\/span><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">\ud83d\udd2c C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul style=\"text-align: justify;\">\n<li data-start=\"1383\" data-end=\"1424\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"1383\" data-end=\"1404\">Thu nh\u1eadn t\u1ebf b\u00e0o T<\/strong> t\u1eeb m\u00e1u b\u1ec7nh nh\u00e2n.<\/span><\/li>\n<li data-start=\"1427\" data-end=\"1522\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"1427\" data-end=\"1449\">K\u1ef9 thu\u1eadt di truy\u1ec1n<\/strong> g\u1eafn th\u1ee5 th\u1ec3 CAR \u0111\u1eb7c hi\u1ec7u (v\u00ed d\u1ee5: CD19 trong NHL, BCMA trong \u0111a u t\u1ee7y).<\/span><\/li>\n<li data-start=\"1525\" data-end=\"1577\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"1525\" data-end=\"1551\">Nh\u00e2n r\u1ed9ng t\u1ebf b\u00e0o CAR-T<\/strong> trong ph\u00f2ng th\u00ed nghi\u1ec7m.<\/span><\/li>\n<li data-start=\"1580\" data-end=\"1671\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"1580\" data-end=\"1612\">Truy\u1ec1n tr\u1edf l\u1ea1i cho b\u1ec7nh nh\u00e2n<\/strong>, gi\u00fap h\u1ec7 mi\u1ec5n d\u1ecbch nh\u1eadn di\u1ec7n v\u00e0 t\u1ea5n c\u00f4ng t\u1ebf b\u00e0o \u00e1c t\u00ednh.<\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify;\" data-start=\"1673\" data-end=\"1865\"><img loading=\"lazy\" class=\"size-medium wp-image-3860 aligncenter\" src=\"https:\/\/hd-med.com\/wp-content\/uploads\/2025\/09\/car-t-cell-therapy-fea-681x400.jpg\" alt=\"\" width=\"681\" height=\"400\" \/><\/p>\n<h2 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"Ung_dung_lam_sang_tai_cac_quoc_gia_phat_trien\"><\/span><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">\u1ee8ng d\u1ee5ng l\u00e2m s\u00e0ng t\u1ea1i c\u00e1c qu\u1ed1c gia ph\u00e1t tri\u1ec3n<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul style=\"text-align: justify;\">\n<li data-start=\"1928\" data-end=\"1986\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"1928\" data-end=\"1938\">Hoa K\u1ef3<\/strong>: FDA \u0111\u00e3 ph\u00ea duy\u1ec7t nhi\u1ec1u li\u1ec7u ph\u00e1p CAR-T, g\u1ed3m:<\/span>\n<ul>\n<li data-start=\"1991\" data-end=\"2067\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"1991\" data-end=\"2038\">Axicabtagene ciloleucel (Yescarta\u00ae, Gilead)<\/strong> cho u lympho t\u1ebf b\u00e0o B l\u1edbn.<\/span><\/li>\n<li data-start=\"2072\" data-end=\"2131\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"2072\" data-end=\"2113\">Tisagenlecleucel (Kymriah\u00ae, Novartis)<\/strong> cho ALL v\u00e0 NHL.<\/span><\/li>\n<li data-start=\"2136\" data-end=\"2253\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"2136\" data-end=\"2194\">Idecabtagene vicleucel (Abecma\u00ae, Bristol Myers Squibb)<\/strong> \u2013 CAR-T \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t cho \u0111a u t\u1ee7y (2021).<\/span><\/li>\n<\/ul>\n<\/li>\n<li data-start=\"2257\" data-end=\"2373\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"2257\" data-end=\"2274\">Ch\u00e2u \u00c2u (EMA)<\/strong>: ph\u00ea duy\u1ec7t CAR-T trong \u0111i\u1ec1u tr\u1ecb <strong data-start=\"2307\" data-end=\"2333\">NHL t\u00e1i ph\u00e1t\/kh\u00e1ng tr\u1ecb<\/strong> v\u00e0 <strong data-start=\"2337\" data-end=\"2349\">\u0111a u t\u1ee7y<\/strong> v\u1edbi k\u1ebft qu\u1ea3 kh\u1ea3 quan.<\/span><\/li>\n<\/ul>\n<h2 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"Bang_chung_nghien_cuu_lam_sang\"><\/span><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">B\u1eb1ng ch\u1ee9ng nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul style=\"text-align: justify;\">\n<li data-start=\"2421\" data-end=\"2637\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">Trong nghi\u00ean c\u1ee9u ZUMA-1 \u0111\u0103ng tr\u00ean <em data-start=\"2455\" data-end=\"2495\">New England Journal of Medicine (2018)<\/em>, t\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng to\u00e0n b\u1ed9 (ORR) \u1edf b\u1ec7nh nh\u00e2n u lympho B l\u1edbn khu\u1ebfch t\u00e1n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb CAR-T \u0111\u1ea1t <strong data-start=\"2587\" data-end=\"2594\">82%<\/strong>, trong \u0111\u00f3 <strong data-start=\"2605\" data-end=\"2630\">54% \u0111\u00e1p \u1ee9ng ho\u00e0n to\u00e0n<\/strong> [1].<\/span><\/li>\n<li data-start=\"2640\" data-end=\"2828\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng KarMMa c\u00f4ng b\u1ed1 tr\u00ean <em data-start=\"2680\" data-end=\"2720\">New England Journal of Medicine (2021)<\/em> cho th\u1ea5y <strong data-start=\"2730\" data-end=\"2741\">ORR 73%<\/strong> \u1edf b\u1ec7nh nh\u00e2n \u0111a u t\u1ee7y kh\u00e1ng tr\u1ecb v\u1edbi nhi\u1ec1u d\u00f2ng \u0111i\u1ec1u tr\u1ecb, s\u1eed d\u1ee5ng CAR-T nh\u1eafm BCMA [2].<\/span><\/li>\n<li data-start=\"2831\" data-end=\"2986\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">M\u1ed9t ph\u00e2n t\u00edch t\u1ed5ng h\u1ee3p tr\u00ean <em data-start=\"2859\" data-end=\"2883\">Lancet Oncology (2020)<\/em> c\u0169ng kh\u1eb3ng \u0111\u1ecbnh CAR-T mang l\u1ea1i t\u1ef7 l\u1ec7 s\u1ed1ng c\u00f2n v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi c\u00e1c ph\u00e1c \u0111\u1ed3 c\u1ee9u v\u00e3n truy\u1ec1n th\u1ed1ng [3].<\/span><\/li>\n<\/ul>\n<h2 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"Uu_diem_cua_CAR-T_trong_u_lympho_khong_Hodgkin_da_u_tuy\"><\/span><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">\u01afu \u0111i\u1ec3m c\u1ee7a CAR-T trong u lympho kh\u00f4ng Hodgkin &amp; \u0111a u t\u1ee7y<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul style=\"text-align: justify;\">\n<li data-start=\"3060\" data-end=\"3127\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">Hi\u1ec7u qu\u1ea3 cao \u1edf b\u1ec7nh nh\u00e2n kh\u00e1ng tr\u1ecb v\u1edbi nhi\u1ec1u d\u00f2ng h\u00f3a tr\u1ecb\/x\u1ea1 tr\u1ecb.<\/span><\/li>\n<li data-start=\"3130\" data-end=\"3174\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">Th\u1eddi gian \u0111\u00e1p \u1ee9ng nhanh v\u00e0 c\u00f3 th\u1ec3 k\u00e9o d\u00e0i.<\/span><\/li>\n<li data-start=\"3177\" data-end=\"3242\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">C\u00e1 th\u1ec3 h\u00f3a \u0111i\u1ec1u tr\u1ecb d\u1ef1a tr\u00ean ch\u00ednh h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh.<\/span><\/li>\n<\/ul>\n<figure id=\"attachment_3861\" aria-describedby=\"caption-attachment-3861\" style=\"width: 632px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" class=\"size-medium wp-image-3861\" src=\"https:\/\/hd-med.com\/wp-content\/uploads\/2025\/09\/116775602_s-1-632x400.jpg\" alt=\"\" width=\"632\" height=\"400\" \/><figcaption id=\"caption-attachment-3861\" class=\"wp-caption-text\">Cancer Immunotherapy as a human immune system therapy concept as a biomedical or biomedicine oncology treatment using the natural T cell fighting properties of the body as a 3D render.<\/figcaption><\/figure>\n<h2 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"Tai_lieu_tham_khao_uy_tin\"><\/span><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">T\u00e0i li\u1ec7u tham kh\u1ea3o uy t\u00edn<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p style=\"text-align: justify;\" data-start=\"3446\" data-end=\"3824\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">[1] Neelapu SS et al. &#8220;Axicabtagene Ciloleucel CAR-T-Cell Therapy in Refractory Large B-Cell Lymphoma.&#8221; <em data-start=\"3550\" data-end=\"3556\">NEJM<\/em>. 2018.<\/span><br data-start=\"3563\" data-end=\"3566\" \/><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">[2] Munshi NC et al. &#8220;Idecabtagene vicleucel in relapsed and refractory multiple myeloma.&#8221; <em data-start=\"3657\" data-end=\"3663\">NEJM<\/em>. 2021.<\/span><br data-start=\"3670\" data-end=\"3673\" \/><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">[3] Locke FL et al. &#8220;Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1).&#8221; <em data-start=\"3798\" data-end=\"3815\">Lancet Oncology<\/em>. 2020.<\/span><\/p>\n<h2 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"Ket_Luan\"><\/span><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">K\u1ebft Lu\u1eadn<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p style=\"text-align: justify;\" data-start=\"4311\" data-end=\"4539\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">\ud83d\udc49 Li\u1ec7u ph\u00e1p <strong data-start=\"4324\" data-end=\"4333\">CAR-T<\/strong> \u0111\u00e3 m\u1edf ra hy v\u1ecdng m\u1edbi cho h\u00e0ng ngh\u00ecn b\u1ec7nh nh\u00e2n u lympho v\u00e0 \u0111a u t\u1ee7y tr\u00ean to\u00e0n c\u1ea7u. Li\u00ean h\u1ec7 ngay <strong data-start=\"4429\" data-end=\"4459\">[T\u00ean ph\u00f2ng kh\u00e1m\/trung t\u00e2m]<\/strong> \u0111\u1ec3 \u0111\u01b0\u1ee3c chuy\u00ean gia t\u01b0 v\u1ea5n chi ti\u1ebft v\u1ec1 ti\u1ec1m n\u0103ng \u1ee9ng d\u1ee5ng trong t\u01b0\u01a1ng lai g\u1ea7n.<\/span><\/p>\n<h2 style=\"text-align: justify;\"><span class=\"ez-toc-section\" id=\"Cau_hoi_thuong_gap_ve_lieu_phap_CAR-T_trong_u_lympho_khong_Hodgkin_va_da_u_tuy\"><\/span><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">C\u00e2u h\u1ecfi th\u01b0\u1eddng g\u1eb7p v\u1ec1 li\u1ec7u ph\u00e1p CAR-T trong u lympho kh\u00f4ng Hodgkin v\u00e0 \u0111a u t\u1ee7y<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p style=\"text-align: justify;\" data-start=\"291\" data-end=\"502\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"291\" data-end=\"321\">Q1: Li\u1ec7u ph\u00e1p CAR-T l\u00e0 g\u00ec?<\/strong><\/span><br data-start=\"321\" data-end=\"324\" \/><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">A1: CAR-T (Chimeric Antigen Receptor T-cell therapy) l\u00e0 ph\u01b0\u01a1ng ph\u00e1p s\u1eed d\u1ee5ng t\u1ebf b\u00e0o T c\u1ee7a ch\u00ednh b\u1ec7nh nh\u00e2n, \u0111\u01b0\u1ee3c t\u00e1i l\u1eadp tr\u00ecnh di truy\u1ec1n \u0111\u1ec3 nh\u1eadn di\u1ec7n v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"504\" data-end=\"717\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"504\" data-end=\"565\">Q2: CAR-T c\u00f3 hi\u1ec7u qu\u1ea3 trong u lympho kh\u00f4ng Hodgkin kh\u00f4ng?<\/strong><\/span><br data-start=\"565\" data-end=\"568\" \/><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">A2: Theo nghi\u00ean c\u1ee9u ZUMA-1 (<em data-start=\"596\" data-end=\"607\">NEJM 2018<\/em>), CAR-T \u0111\u1ea1t t\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng to\u00e0n b\u1ed9 l\u00ean t\u1edbi <strong data-start=\"650\" data-end=\"657\">82%<\/strong> \u1edf b\u1ec7nh nh\u00e2n u lympho B l\u1edbn khu\u1ebfch t\u00e1n t\u00e1i ph\u00e1t\/kh\u00e1ng tr\u1ecb.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"719\" data-end=\"901\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"719\" data-end=\"779\">Q3: Li\u1ec7u ph\u00e1p CAR-T \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t cho \u0111a u t\u1ee7y ch\u01b0a?<\/strong><\/span><br data-start=\"779\" data-end=\"782\" \/><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">A3: C\u00f3. FDA \u0111\u00e3 ph\u00ea duy\u1ec7t <strong data-start=\"807\" data-end=\"843\">Idecabtagene vicleucel (Abecma\u00ae)<\/strong> v\u00e0o n\u0103m 2021 cho b\u1ec7nh nh\u00e2n \u0111a u t\u1ee7y t\u00e1i ph\u00e1t\/kh\u00e1ng tr\u1ecb.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"903\" data-end=\"1086\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"903\" data-end=\"934\">Q4: CAR-T c\u00f3 an to\u00e0n kh\u00f4ng?<\/strong><\/span><br data-start=\"934\" data-end=\"937\" \/><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">A4: CAR-T c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 h\u1ed9i ch\u1ee9ng gi\u1ea3i ph\u00f3ng cytokine (CRS), nh\u01b0ng \u0111a s\u1ed1 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t nh\u1edd ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb h\u1ed7 tr\u1ee3.<\/span><\/p>\n<p style=\"text-align: justify;\" data-start=\"1088\" data-end=\"1310\"><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\"><strong data-start=\"1088\" data-end=\"1136\">Q5: CAR-T c\u00f3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng t\u1ea1i Vi\u1ec7t Nam ch\u01b0a?<\/strong><\/span><br data-start=\"1136\" data-end=\"1139\" \/><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 120%;\">A5: Hi\u1ec7n nay, li\u1ec7u ph\u00e1p CAR-T ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c tri\u1ec3n khai t\u1ea1i M\u1ef9, Ch\u00e2u \u00c2u, Trung Qu\u1ed1c. \u1ede Vi\u1ec7t Nam, m\u1ed9t s\u1ed1 trung t\u00e2m \u0111ang nghi\u00ean c\u1ee9u v\u00e0 chu\u1ea9n b\u1ecb cho \u1ee9ng d\u1ee5ng trong t\u01b0\u01a1ng lai.<\/span><\/p>\n<p style=\"text-align: justify;\">\n","protected":false},"excerpt":{"rendered":"<p>Gi\u1edbi thi\u1ec7u Li\u1ec7u ph\u00e1p CAR-T (Chimeric Antigen Receptor T-cell therapy) \u0111\u01b0\u1ee3c coi l\u00e0 m\u1ed9t trong nh\u1eefng b\u01b0\u1edbc ngo\u1eb7t c\u1ee7a y h\u1ecdc hi\u1ec7n \u0111\u1ea1i trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 huy\u1ebft h\u1ecdc. Thay v\u00ec h\u00f3a tr\u1ecb hay x\u1ea1 tr\u1ecb truy\u1ec1n th\u1ed1ng, CAR-T t\u1eadn d\u1ee5ng ch\u00ednh t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n, t\u00e1i l\u1eadp tr\u00ecnh \u0111\u1ec3 nh\u1eadn [&#8230;]\n","protected":false},"author":2,"featured_media":2271,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1,9,11],"tags":[],"_links":{"self":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2270"}],"collection":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2270"}],"version-history":[{"count":3,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2270\/revisions"}],"predecessor-version":[{"id":2281,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2270\/revisions\/2281"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/media\/2271"}],"wp:attachment":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2270"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}