{"id":2306,"date":"2025-10-06T06:33:08","date_gmt":"2025-10-06T06:33:08","guid":{"rendered":"https:\/\/lieuphapyhoctaitao.com\/?p=2306"},"modified":"2025-10-06T06:39:00","modified_gmt":"2025-10-06T06:39:00","slug":"%f0%9f%8e%af%f0%9f%8e%af%f0%9f%8e%afcar-nk-lieu-phap-te-bao-mien-dich-the-he-moi-trong-dieu-tri-ung-thu","status":"publish","type":"post","link":"https:\/\/lieuphapyhoctaitao.com\/?p=2306","title":{"rendered":"\ud83c\udfaf\ud83c\udfaf\ud83c\udfafCAR-NK: Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch th\u1ebf h\u1ec7 m\u1edbi trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0"},"content":{"rendered":"<h2><\/h2>\n<h1><span class=\"ez-toc-section\" id=\"Mo_dau_Cuoc_cach_mang_cua_lieu_phap_te_bao\"><\/span>M\u1edf \u0111\u1ea7u: Cu\u1ed9c c\u00e1ch m\u1ea1ng c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o<span class=\"ez-toc-section-end\"><\/span><\/h1><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">N\u00d4\u0323I DUNG:<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#Mo_dau_Cuoc_cach_mang_cua_lieu_phap_te_bao\" >M\u1edf \u0111\u1ea7u: Cu\u1ed9c c\u00e1ch m\u1ea1ng c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#Te_bao_NK_va_co_che_hoat_dong_tu_nhien\" >T\u1ebf b\u00e0o NK v\u00e0 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng t\u1ef1 nhi\u00ean<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#CAR_la_gi_va_khi_gan_vao_NK_thi_co_gi_dac_biet\" >CAR l\u00e0 g\u00ec v\u00e0 khi g\u1eafn v\u00e0o NK th\u00ec c\u00f3 g\u00ec \u0111\u1eb7c bi\u1ec7t?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#_Uu_diem_noi_bat_cua_CAR-NK\" >\u00a0\u01afu \u0111i\u1ec3m n\u1ed5i b\u1eadt c\u1ee7a CAR-NK<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#_Bang_chung_lam_sang_CAR-NK_trong_thuc_te\" >\u00a0B\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng: CAR-NK trong th\u1ef1c t\u1ebf<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#_Nghien_cuu_tai_My_Cord_blood_CAR19IL-15\" >\u00a0Nghi\u00ean c\u1ee9u t\u1ea1i M\u1ef9 (Cord blood CAR19\/IL-15)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#_San_pham_FT596_Fate_Therapeutics\" >\u00a0S\u1ea3n ph\u1ea9m FT596 (Fate Therapeutics)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#_Tong_quan_he_thong_2024%E2%80%932025\" >\u00a0T\u1ed5ng quan h\u1ec7 th\u1ed1ng (2024\u20132025)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#_FDA_da_phe_duyet_chua\" >\u00a0FDA \u0111\u00e3 ph\u00ea duy\u1ec7t ch\u01b0a?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#_Thach_thuc_can_vuot_qua\" >\u00a0Th\u00e1ch th\u1ee9c c\u1ea7n v\u01b0\u1ee3t qua<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#Tuong_lai_cua_CAR-NK\" >T\u01b0\u01a1ng lai c\u1ee7a CAR-NK<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#CAR-NK_so_voi_CAR-T_Bang_so_sanh_don_gian\" >CAR-NK so v\u1edbi CAR-T: B\u1ea3ng so s\u00e1nh \u0111\u01a1n gi\u1ea3n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/lieuphapyhoctaitao.com\/?p=2306\/#Ket_luan\" >K\u1ebft lu\u1eadn<\/a><\/li><\/ul><\/nav><\/div>\n\n<p data-start=\"526\" data-end=\"829\">Trong 10 n\u0103m qua, y h\u1ecdc \u0111\u00e3 ch\u1ee9ng ki\u1ebfn s\u1ef1 b\u00f9ng n\u1ed5 c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch, \u0111\u1eb7c bi\u1ec7t l\u00e0 <strong data-start=\"616\" data-end=\"625\">CAR-T<\/strong> \u2013 lo\u1ea1i \u201cthu\u1ed1c s\u1ed1ng\u201d s\u1eed d\u1ee5ng ch\u00ednh t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 ti\u00eau di\u1ec7t ung th\u01b0. Tuy nhi\u00ean, CAR-T c\u0169ng \u0111i k\u00e8m nhi\u1ec1u h\u1ea1n ch\u1ebf: <strong data-start=\"757\" data-end=\"826\">chi ph\u00ed cao, th\u1eddi gian s\u1ea3n xu\u1ea5t l\u00e2u, v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng<\/strong>.<\/p>\n<p data-start=\"831\" data-end=\"1100\">Trong b\u1ed1i c\u1ea3nh \u0111\u00f3, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang ph\u00e1t tri\u1ec3n m\u1ed9t h\u01b0\u1edbng \u0111i m\u1edbi: <strong data-start=\"901\" data-end=\"962\">CAR-NK (Chimeric Antigen Receptor \u2013 Natural Killer cells)<\/strong>. \u0110\u00e2y l\u00e0 li\u1ec7u ph\u00e1p s\u1eed d\u1ee5ng <strong data-start=\"989\" data-end=\"1034\">t\u1ebf b\u00e0o NK \u2013 \u201cs\u00e1t th\u1ee7 t\u1ef1 nhi\u00ean\u201d c\u1ee7a c\u01a1 th\u1ec3<\/strong> \u2013 \u0111\u01b0\u1ee3c trang b\u1ecb th\u00eam v\u0169 kh\u00ed c\u00f4ng ngh\u1ec7 gen \u0111\u1ec3 nh\u1eafm \u0111\u00fang ung th\u01b0.<\/p>\n<p data-start=\"1102\" data-end=\"1341\">\ud83d\udca1 H\u00ecnh dung \u0111\u01a1n gi\u1ea3n: n\u1ebfu h\u1ec7 mi\u1ec5n d\u1ecbch l\u00e0 m\u1ed9t \u0111\u1ed9i qu\u00e2n, th\u00ec NK cell l\u00e0 nh\u1eefng \u201c\u0111\u1eb7c nhi\u1ec7m\u201d chuy\u00ean ph\u00e1t hi\u1ec7n v\u00e0 lo\u1ea1i b\u1ecf k\u1ebb \u0111\u1ecbch. CAR-NK bi\u1ebfn c\u00e1c \u0111\u1eb7c nhi\u1ec7m n\u00e0y th\u00e0nh \u201cchi\u1ebfn binh \u0111\u01b0\u1ee3c n\u00e2ng c\u1ea5p\u201d, c\u00f3 radar nh\u1eadn di\u1ec7n ch\u00ednh x\u00e1c m\u1ee5c ti\u00eau ung th\u01b0.<\/p>\n<h1 data-start=\"1348\" data-end=\"1394\"><span class=\"ez-toc-section\" id=\"Te_bao_NK_va_co_che_hoat_dong_tu_nhien\"><\/span>T\u1ebf b\u00e0o NK v\u00e0 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng t\u1ef1 nhi\u00ean<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong data-start=\"1397\" data-end=\"1415\">NK cell l\u00e0 g\u00ec?<\/strong><br data-start=\"1415\" data-end=\"1418\" \/>NK (Natural Killer) l\u00e0 lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch b\u1ea9m sinh, c\u00f3 kh\u1ea3 n\u0103ng nh\u1eadn di\u1ec7n v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o b\u1ea5t th\u01b0\u1eddng m\u00e0 <strong data-start=\"1531\" data-end=\"1561\">kh\u00f4ng c\u1ea7n hu\u1ea5n luy\u1ec7n tr\u01b0\u1edbc<\/strong>.<\/p>\n<p><strong data-start=\"1568\" data-end=\"1598\">C\u01a1 ch\u1ebf ti\u00eau di\u1ec7t t\u1ef1 nhi\u00ean:<\/strong><\/p>\n<p>Nh\u1eadn di\u1ec7n t\u1ebf b\u00e0o thi\u1ebfu \u201ct\u00edn hi\u1ec7u an to\u00e0n\u201d (MHC I).<\/p>\n<p>Gi\u1ea3i ph\u00f3ng perforin v\u00e0 granzymes \u0111\u1ec3 ti\u00eau di\u1ec7t.<\/p>\n<p>K\u00edch ho\u1ea1t t\u00edn hi\u1ec7u g\u00e2y ch\u1ebft t\u1ebf b\u00e0o (apoptosis).<\/p>\n<p data-start=\"1766\" data-end=\"1920\">So v\u1edbi t\u1ebf b\u00e0o T, NK cell linh ho\u1ea1t h\u01a1n v\u00ec <strong data-start=\"1808\" data-end=\"1843\">kh\u00f4ng c\u1ea7n kh\u00e1ng nguy\u00ean \u0111\u1eb7c hi\u1ec7u<\/strong>. \u0110\u00e2y ch\u00ednh l\u00e0 n\u1ec1n t\u1ea3ng \u0111\u1ec3 NK tr\u1edf th\u00e0nh l\u1ef1a ch\u1ecdn l\u00fd t\u01b0\u1edfng cho k\u1ef9 thu\u1eadt CAR.<\/p>\n<h3><img loading=\"lazy\" class=\"wp-image-3881 alignright\" src=\"https:\/\/hd-med.com\/wp-content\/uploads\/2025\/10\/natural-killer-cells-attack-28144-582x400.jpg\" alt=\"\" width=\"431\" height=\"296\" \/><\/h3>\n<h1 data-start=\"1927\" data-end=\"1982\"><span class=\"ez-toc-section\" id=\"CAR_la_gi_va_khi_gan_vao_NK_thi_co_gi_dac_biet\"><\/span>CAR l\u00e0 g\u00ec v\u00e0 khi g\u1eafn v\u00e0o NK th\u00ec c\u00f3 g\u00ec \u0111\u1eb7c bi\u1ec7t?<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong data-start=\"1985\" data-end=\"2021\">CAR (Chimeric Antigen Receptor):<\/strong> m\u1ed9t lo\u1ea1i th\u1ee5 th\u1ec3 nh\u00e2n t\u1ea1o \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf trong ph\u00f2ng th\u00ed nghi\u1ec7m. CAR gi\u00fap t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch nh\u1eadn di\u1ec7n m\u1ed9t protein c\u1ee5 th\u1ec3 tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o ung th\u01b0 (v\u00ed d\u1ee5: CD19 \u1edf ung th\u01b0 m\u00e1u).<\/p>\n<p>Khi <strong data-start=\"2206\" data-end=\"2229\">g\u1eafn CAR v\u00e0o NK cell<\/strong>, ta c\u00f3:<\/p>\n<p><strong data-start=\"2244\" data-end=\"2266\">T\u0103ng \u0111\u1ed9 ch\u00ednh x\u00e1c:<\/strong> NK s\u1ebd kh\u00f4ng b\u1eafn nh\u1ea7m \u201cqu\u00e2n ta\u201d.<\/p>\n<p><strong data-start=\"2305\" data-end=\"2328\">K\u1ebft h\u1ee3p hai c\u01a1 ch\u1ebf:<\/strong> v\u1eeba ti\u00eau di\u1ec7t theo CAR, v\u1eeba theo c\u01a1 ch\u1ebf t\u1ef1 nhi\u00ean.<\/p>\n<p><strong data-start=\"2385\" data-end=\"2413\">C\u00f3 th\u1ec3 d\u00f9ng ngu\u1ed3n chung:<\/strong> NK t\u1eeb m\u00e1u cu\u1ed1ng r\u1ed1n, t\u1ebf b\u00e0o g\u1ed1c iPSC, thay v\u00ec l\u1ea5y t\u1eeb ch\u00ednh b\u1ec7nh nh\u00e2n.<\/p>\n<p data-start=\"2487\" data-end=\"2593\">\ud83d\udc49 N\u00f3i c\u00e1ch kh\u00e1c: CAR-NK l\u00e0 <strong data-start=\"2515\" data-end=\"2537\">phi\u00ean b\u1ea3n n\u00e2ng c\u1ea5p<\/strong> v\u1eeba th\u00f4ng minh h\u01a1n, v\u1eeba d\u1ec5 s\u1ea3n xu\u1ea5t h\u01a1n so v\u1edbi CAR-T.<\/p>\n<h1 data-start=\"2600\" data-end=\"2634\"><span class=\"ez-toc-section\" id=\"_Uu_diem_noi_bat_cua_CAR-NK\"><\/span>\u00a0\u01afu \u0111i\u1ec3m n\u1ed5i b\u1eadt c\u1ee7a CAR-NK<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<ol>\n<li data-start=\"2638\" data-end=\"2728\"><strong data-start=\"2638\" data-end=\"2660\">An to\u00e0n h\u01a1n CAR-T:<\/strong> \u00edt g\u1eb7p h\u1ed9i ch\u1ee9ng gi\u1ea3i ph\u00f3ng cytokine (CRS) v\u00e0 \u0111\u1ed9c t\u00ednh th\u1ea7n kinh.<\/li>\n<li data-start=\"2732\" data-end=\"2819\"><strong data-start=\"2732\" data-end=\"2768\">C\u00f3 th\u1ec3 d\u00f9ng cho nhi\u1ec1u b\u1ec7nh nh\u00e2n:<\/strong> s\u1ea3n xu\u1ea5t \u201coff-the-shelf\u201d gi\u1ed1ng nh\u01b0 thu\u1ed1c s\u1eb5n c\u00f3.<\/li>\n<li data-start=\"2823\" data-end=\"2913\"><strong data-start=\"2823\" data-end=\"2846\">\u0110a c\u01a1 ch\u1ebf t\u1ea5n c\u00f4ng:<\/strong> ngo\u00e0i CAR, NK c\u00f2n c\u00f3 kh\u1ea3 n\u0103ng t\u1ef1 nhi\u00ean ch\u1ed1ng l\u1ea1i t\u1ebf b\u00e0o ung th\u01b0.<\/li>\n<li data-start=\"2917\" data-end=\"2995\"><strong data-start=\"2917\" data-end=\"2948\">Chi ph\u00ed ti\u1ec1m n\u0103ng th\u1ea5p h\u01a1n:<\/strong> v\u00ec c\u00f3 th\u1ec3 s\u1ea3n xu\u1ea5t h\u00e0ng lo\u1ea1t t\u1eeb ngu\u1ed3n chung.<\/li>\n<\/ol>\n<h1 data-start=\"3002\" data-end=\"3051\"><span class=\"ez-toc-section\" id=\"_Bang_chung_lam_sang_CAR-NK_trong_thuc_te\"><\/span>\u00a0B\u1eb1ng ch\u1ee9ng l\u00e2m s\u00e0ng: CAR-NK trong th\u1ef1c t\u1ebf<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p data-start=\"3052\" data-end=\"3110\">M\u1eb7c d\u00f9 c\u00f2n m\u1edbi, nhi\u1ec1u th\u1eed nghi\u1ec7m \u0111\u00e3 cho k\u1ebft qu\u1ea3 h\u1ee9a h\u1eb9n:<\/p>\n<h2 data-start=\"3112\" data-end=\"3165\"><span class=\"ez-toc-section\" id=\"_Nghien_cuu_tai_My_Cord_blood_CAR19IL-15\"><\/span>\u00a0Nghi\u00ean c\u1ee9u t\u1ea1i M\u1ef9 (Cord blood CAR19\/IL-15)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong data-start=\"3168\" data-end=\"3179\">Quy m\u00f4:<\/strong> 37 b\u1ec7nh nh\u00e2n ung th\u01b0 m\u00e1u (leukemia, lymphoma).<\/p>\n<p><strong data-start=\"3231\" data-end=\"3243\">K\u1ebft qu\u1ea3:<\/strong> t\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng t\u1ed1t, m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n \u0111\u1ea1t lui b\u1ec7nh ho\u00e0n to\u00e0n.<\/p>\n<p><strong data-start=\"3308\" data-end=\"3320\">An to\u00e0n:<\/strong> kh\u00f4ng ghi nh\u1eadn CRS nghi\u00eam tr\u1ecdng hay \u0111\u1ed9c t\u00ednh th\u1ea7n kinh.<br data-start=\"3376\" data-end=\"3379\" \/>\u27a1\ufe0f \u0110\u00e2y l\u00e0 nghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean ch\u1ee9ng minh CAR-NK <strong data-start=\"3427\" data-end=\"3479\">c\u00f3 hi\u1ec7u qu\u1ea3 l\u00e2m s\u00e0ng r\u00f5 r\u1ec7t v\u00e0 an to\u00e0n h\u01a1n CAR-T<\/strong>.<\/p>\n<h2 data-start=\"3485\" data-end=\"3530\"><span class=\"ez-toc-section\" id=\"_San_pham_FT596_Fate_Therapeutics\"><\/span>\u00a0S\u1ea3n ph\u1ea9m FT596 (Fate Therapeutics)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong data-start=\"3533\" data-end=\"3547\">Ngu\u1ed3n g\u1ed1c:<\/strong> t\u1ebf b\u00e0o g\u1ed1c iPSC, \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh \u0111\u1ec3 bi\u1ec3u hi\u1ec7n CAR, IL-15 v\u00e0 CD16 (t\u0103ng kh\u1ea3 n\u0103ng ADCC).<\/p>\n<p><strong data-start=\"3638\" data-end=\"3653\">T\u00ecnh tr\u1ea1ng:<\/strong> \u0111\u01b0\u1ee3c FDA c\u1ea5p ph\u00e9p IND, th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng phase I.<\/p>\n<p><strong data-start=\"3710\" data-end=\"3730\">K\u1ebft qu\u1ea3 ban \u0111\u1ea7u:<\/strong> m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n ung th\u01b0 m\u00e1u c\u00f3 \u0111\u00e1p \u1ee9ng t\u00edch c\u1ef1c, an to\u00e0n ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c.<\/p>\n<h2 data-start=\"3809\" data-end=\"3850\"><span class=\"ez-toc-section\" id=\"_Tong_quan_he_thong_2024%E2%80%932025\"><\/span>\u00a0T\u1ed5ng quan h\u1ec7 th\u1ed1ng (2024\u20132025)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>H\u01a1n 40 th\u1eed nghi\u1ec7m CAR-NK \u0111\u01b0\u1ee3c \u0111\u0103ng k\u00fd to\u00e0n c\u1ea7u, tr\u1ea3i d\u00e0i t\u1eeb ung th\u01b0 m\u00e1u \u0111\u1ebfn ung th\u01b0 r\u1eafn.<\/p>\n<p>T\u1ef7 l\u1ec7 t\u00e1c d\u1ee5ng ph\u1ee5 th\u1ea5p h\u01a1n CAR-T r\u00f5 r\u1ec7t.<\/p>\n<p>Hi\u1ec7u qu\u1ea3 \u1edf ung th\u01b0 r\u1eafn v\u1eabn h\u1ea1n ch\u1ebf, c\u1ea7n t\u1ed1i \u01b0u th\u00eam.<\/p>\n<h2><img loading=\"lazy\" class=\"size-medium wp-image-3879 aligncenter\" src=\"https:\/\/hd-med.com\/wp-content\/uploads\/2025\/10\/CARNK_Cancerwise.png.resize.702.404-695x400.jpg\" alt=\"\" width=\"695\" height=\"400\" \/><\/h2>\n<h1 data-start=\"4054\" data-end=\"4084\"><span class=\"ez-toc-section\" id=\"_FDA_da_phe_duyet_chua\"><\/span>\u00a0FDA \u0111\u00e3 ph\u00ea duy\u1ec7t ch\u01b0a?<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong data-start=\"4087\" data-end=\"4115\">Th\u1ef1c t\u1ebf hi\u1ec7n nay (2025):<\/strong> ch\u01b0a c\u00f3 s\u1ea3n ph\u1ea9m CAR-NK n\u00e0o \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t \u0111\u1ec3 l\u01b0u h\u00e0nh ch\u00ednh th\u1ee9c.<\/p>\n<p><strong data-start=\"4191\" data-end=\"4205\">Tuy nhi\u00ean:<\/strong> nhi\u1ec1u s\u1ea3n ph\u1ea9m \u0111\u00e3 \u0111\u01b0\u1ee3c FDA c\u1ea5p ph\u00e9p th\u1eed nghi\u1ec7m (IND). V\u00ed d\u1ee5: FT596, FT576.<\/p>\n<p><strong data-start=\"4285\" data-end=\"4307\">\u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a:<\/strong> CAR-NK \u0111ang \u1edf giai \u0111o\u1ea1n th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, <strong data-start=\"4353\" data-end=\"4399\">ch\u01b0a th\u1ec3 s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i ngo\u00e0i nghi\u00ean c\u1ee9u<\/strong>.<\/p>\n<h1><\/h1>\n<h1 data-start=\"4410\" data-end=\"4441\"><span class=\"ez-toc-section\" id=\"_Thach_thuc_can_vuot_qua\"><\/span>\u00a0Th\u00e1ch th\u1ee9c c\u1ea7n v\u01b0\u1ee3t qua<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<ol>\n<li data-start=\"4445\" data-end=\"4522\"><strong data-start=\"4445\" data-end=\"4465\">Tu\u1ed5i th\u1ecd t\u1ebf b\u00e0o:<\/strong> NK th\u01b0\u1eddng t\u1ed3n t\u1ea1i ng\u1eafn h\u01a1n so v\u1edbi T cell trong c\u01a1 th\u1ec3.<\/li>\n<li data-start=\"4526\" data-end=\"4606\"><strong data-start=\"4526\" data-end=\"4550\">Ung th\u01b0 r\u1eafn kh\u00f3 tr\u1ecb:<\/strong> vi m\u00f4i tr\u01b0\u1eddng kh\u1ed1i u (TME) ch\u1ee9a nhi\u1ec1u ch\u1ea5t \u1ee9c ch\u1ebf NK.<\/li>\n<li data-start=\"4610\" data-end=\"4704\"><strong data-start=\"4610\" data-end=\"4634\">S\u1ea3n xu\u1ea5t quy m\u00f4 l\u1edbn:<\/strong> c\u1ea7n c\u00f4ng ngh\u1ec7 nu\u00f4i c\u1ea5y v\u00e0 chu\u1ea9n h\u00f3a s\u1ea3n ph\u1ea9m \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o ch\u1ea5t l\u01b0\u1ee3ng.<\/li>\n<li data-start=\"4708\" data-end=\"4798\"><strong data-start=\"4708\" data-end=\"4728\">Chi ph\u00ed ban \u0111\u1ea7u:<\/strong> m\u1eb7c d\u00f9 ti\u1ec1m n\u0103ng r\u1ebb h\u01a1n CAR-T, hi\u1ec7n t\u1ea1i chi ph\u00ed nghi\u00ean c\u1ee9u v\u1eabn cao.<\/li>\n<\/ol>\n<h1 data-start=\"4805\" data-end=\"4833\"><span class=\"ez-toc-section\" id=\"Tuong_lai_cua_CAR-NK\"><\/span>T\u01b0\u01a1ng lai c\u1ee7a CAR-NK<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p><strong data-start=\"4836\" data-end=\"4859\">C\u1ea3i ti\u1ebfn c\u00f4ng ngh\u1ec7:<\/strong> th\u00eam gen IL-15, s\u1eed d\u1ee5ng CRISPR \u0111\u1ec3 ch\u1ed1ng \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch.<\/p>\n<p><strong data-start=\"4922\" data-end=\"4944\">K\u1ebft h\u1ee3p li\u1ec7u ph\u00e1p:<\/strong> CAR-NK + kh\u00e1ng th\u1ec3, ho\u1eb7c CAR-NK + thu\u1ed1c mi\u1ec5n d\u1ecbch kh\u00e1c.<\/p>\n<p><strong data-start=\"5005\" data-end=\"5031\">S\u1ea3n xu\u1ea5t iPSC-derived:<\/strong> gi\u00fap t\u1ea1o ngu\u1ed3n \u201cv\u00f4 t\u1eadn\u201d v\u00e0 \u0111\u1ed3ng nh\u1ea5t cho nhi\u1ec1u b\u1ec7nh nh\u00e2n.<\/p>\n<p><strong data-start=\"5094\" data-end=\"5112\">\u1ee8ng d\u1ee5ng r\u1ed9ng:<\/strong> n\u1ebfu th\u00e0nh c\u00f4ng, CAR-NK c\u00f3 th\u1ec3 m\u1edf ra k\u1ef7 nguy\u00ean m\u1edbi trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 m\u00e1u, th\u1eadm ch\u00ed c\u1ea3 u r\u1eafn.<\/p>\n<h1 data-start=\"5218\" data-end=\"5268\"><span class=\"ez-toc-section\" id=\"CAR-NK_so_voi_CAR-T_Bang_so_sanh_don_gian\"><\/span>CAR-NK so v\u1edbi CAR-T: B\u1ea3ng so s\u00e1nh \u0111\u01a1n gi\u1ea3n<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<table data-start=\"5270\" data-end=\"5720\">\n<thead data-start=\"5270\" data-end=\"5301\">\n<tr data-start=\"5270\" data-end=\"5301\">\n<td><strong>\u0110\u1eb7c \u0111i\u1ec3m<\/strong><\/td>\n<td><strong>CAR-T<\/strong><\/td>\n<td><strong>CAR-NK<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr data-start=\"5334\" data-end=\"5439\">\n<td data-start=\"5334\" data-end=\"5349\" data-col-size=\"sm\">Ngu\u1ed3n t\u1ebf b\u00e0o<\/td>\n<td data-start=\"5349\" data-end=\"5387\" data-col-size=\"md\">L\u1ea5y t\u1eeb ch\u00ednh b\u1ec7nh nh\u00e2n (autologous)<\/td>\n<td data-start=\"5387\" data-end=\"5439\" data-col-size=\"md\">C\u00f3 th\u1ec3 l\u1ea5y t\u1eeb m\u00e1u cu\u1ed1ng r\u1ed1n, iPSC (allogeneic)<\/td>\n<\/tr>\n<tr data-start=\"5440\" data-end=\"5516\">\n<td data-start=\"5440\" data-end=\"5450\" data-col-size=\"sm\">An to\u00e0n<\/td>\n<td data-start=\"5450\" data-end=\"5488\" data-col-size=\"md\">Nguy c\u01a1 CRS, \u0111\u1ed9c t\u00ednh th\u1ea7n kinh cao<\/td>\n<td data-start=\"5488\" data-end=\"5516\" data-col-size=\"md\">Nguy c\u01a1 th\u1ea5p h\u01a1n nhi\u1ec1u<\/td>\n<\/tr>\n<tr data-start=\"5517\" data-end=\"5610\">\n<td data-start=\"5517\" data-end=\"5528\" data-col-size=\"sm\">S\u1ea3n xu\u1ea5t<\/td>\n<td data-start=\"5528\" data-end=\"5556\" data-col-size=\"md\">C\u00e1 th\u1ec3 h\u00f3a, t\u1ed1n th\u1eddi gian<\/td>\n<td data-start=\"5556\" data-end=\"5610\" data-col-size=\"md\">C\u00f3 th\u1ec3 \u201coff-the-shelf\u201d, d\u00f9ng cho nhi\u1ec1u b\u1ec7nh nh\u00e2n<\/td>\n<\/tr>\n<tr data-start=\"5611\" data-end=\"5720\">\n<td data-start=\"5611\" data-end=\"5622\" data-col-size=\"sm\">Hi\u1ec7u qu\u1ea3<\/td>\n<td data-start=\"5622\" data-end=\"5674\" data-col-size=\"md\">\u0110\u00e3 \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t, hi\u1ec7u qu\u1ea3 cao \u1edf ung th\u01b0 m\u00e1u<\/td>\n<td data-start=\"5674\" data-end=\"5720\" data-col-size=\"md\">K\u1ebft qu\u1ea3 s\u1edbm h\u1ee9a h\u1eb9n, c\u1ea7n th\u00eam nghi\u00ean c\u1ee9u<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><img loading=\"lazy\" class=\"size-medium wp-image-3880 aligncenter\" src=\"https:\/\/hd-med.com\/wp-content\/uploads\/2025\/10\/carnk1-711x400.jpg\" alt=\"\" width=\"711\" height=\"400\" \/><\/h2>\n<h1 data-start=\"5727\" data-end=\"5744\"><span class=\"ez-toc-section\" id=\"Ket_luan\"><\/span>K\u1ebft lu\u1eadn<span class=\"ez-toc-section-end\"><\/span><\/h1>\n<p data-start=\"5745\" data-end=\"5970\">CAR-NK l\u00e0 m\u1ed9t trong nh\u1eefng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch <strong data-start=\"5791\" data-end=\"5818\">ti\u1ec1m n\u0103ng nh\u1ea5t hi\u1ec7n nay<\/strong>, \u0111\u1eb7c bi\u1ec7t nh\u1edd <strong data-start=\"5833\" data-end=\"5880\">t\u00ednh an to\u00e0n v\u00e0 kh\u1ea3 n\u0103ng s\u1ea3n xu\u1ea5t h\u00e0ng lo\u1ea1t<\/strong>. Tuy nhi\u00ean, li\u1ec7u ph\u00e1p n\u00e0y v\u1eabn \u0111ang trong giai \u0111o\u1ea1n th\u1eed nghi\u1ec7m, ch\u01b0a \u0111\u01b0\u1ee3c FDA ph\u00ea duy\u1ec7t.<\/p>\n<p data-start=\"5972\" data-end=\"6172\">Trong 5\u201310 n\u0103m t\u1edbi, CAR-NK c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh b\u01b0\u1edbc ngo\u1eb7t quan tr\u1ecdng, m\u1edf r\u1ed9ng kh\u1ea3 n\u0103ng \u0111i\u1ec1u tr\u1ecb ung th\u01b0 cho nhi\u1ec1u b\u1ec7nh nh\u00e2n, v\u1edbi hy v\u1ecdng <strong data-start=\"6106\" data-end=\"6145\">gi\u00e1 th\u00e0nh h\u1ee3p l\u00fd h\u01a1n v\u00e0 an to\u00e0n h\u01a1n<\/strong> so v\u1edbi c\u00e1c th\u1ebf h\u1ec7 tr\u01b0\u1edbc.<\/p>\n<p data-start=\"6211\" data-end=\"6424\">\u201cB\u1ea1n quan t\u00e2m \u0111\u1ebfn c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch th\u1ebf h\u1ec7 m\u1edbi nh\u01b0 CAR-NK?<br data-start=\"6275\" data-end=\"6278\" \/>\ud83d\udc49 \u0110\u0103ng k\u00fd nh\u1eadn b\u1ea3n tin \u0111\u1ec3 c\u1eadp nh\u1eadt k\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng m\u1edbi nh\u1ea5t, c\u01a1 h\u1ed9i tham gia nghi\u00ean c\u1ee9u, v\u00e0 xu h\u01b0\u1edbng \u0111i\u1ec1u tr\u1ecb ung th\u01b0 t\u01b0\u01a1ng lai.\u201d<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>M\u1edf \u0111\u1ea7u: Cu\u1ed9c c\u00e1ch m\u1ea1ng c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o Trong 10 n\u0103m qua, y h\u1ecdc \u0111\u00e3 ch\u1ee9ng ki\u1ebfn s\u1ef1 b\u00f9ng n\u1ed5 c\u1ee7a c\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch, \u0111\u1eb7c bi\u1ec7t l\u00e0 CAR-T \u2013 lo\u1ea1i \u201cthu\u1ed1c s\u1ed1ng\u201d s\u1eed d\u1ee5ng ch\u00ednh t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 ti\u00eau di\u1ec7t ung th\u01b0. Tuy nhi\u00ean, CAR-T c\u0169ng [&#8230;]\n","protected":false},"author":2,"featured_media":2308,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1,9,11],"tags":[],"_links":{"self":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2306"}],"collection":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2306"}],"version-history":[{"count":6,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2306\/revisions"}],"predecessor-version":[{"id":2315,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2306\/revisions\/2315"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/media\/2308"}],"wp:attachment":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2306"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2306"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2306"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}