{"id":2343,"date":"2026-08-17T07:26:07","date_gmt":"2026-08-17T07:26:07","guid":{"rendered":"https:\/\/lieuphapyhoctaitao.com\/?p=2343"},"modified":"2026-08-17T07:36:23","modified_gmt":"2026-08-17T07:36:23","slug":"%f0%9f%8e%af%f0%9f%8e%af%f0%9f%8e%af-lieu-phap-te-bao-goc-va-hiv-mot-chuong-moi-trong-hanh-trinh-tim-kiem-phuong-phap-chua-tri","status":"publish","type":"post","link":"https:\/\/lieuphapyhoctaitao.com\/?p=2343","title":{"rendered":"\ud83c\udfaf\ud83c\udfaf\ud83c\udfaf Li\u1ec7u ph\u00e1p T\u1ebf b\u00e0o G\u1ed1c v\u00e0 HIV: M\u1ed9t Ch\u01b0\u01a1ng M\u1edbi Trong H\u00e0nh Tr\u00ecnh T\u00ecm Ki\u1ebfm Ph\u01b0\u01a1ng Ph\u00e1p Ch\u1eefa Tr\u1ecb"},"content":{"rendered":"

<\/h1>\n

Li\u1ec7u c\u1ea5y gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c c\u00f3 th\u1ec3 gi\u00fap ng\u01b0\u1eddi nhi\u1ec5m HIV \u0111\u1ea1t tr\u1ea1ng th\u00e1i thuy\u00ean gi\u1ea3m l\u00e2u d\u00e0i m\u00e0 kh\u00f4ng nh\u1ea5t thi\u1ebft ph\u1ea3i s\u1edf h\u1eefu hai b\u1ea3n sao \u0111\u1ed9t bi\u1ebfn CCR5\u039432?<\/strong><\/span><\/p>\n

M\u1ed9t nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean Nature<\/em> v\u00e0o th\u00e1ng 12\/2025 \u0111ang mang \u0111\u1ebfn m\u1ed9t g\u00f3c nh\u00ecn quan tr\u1ecdng cho l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u ch\u1eefa tr\u1ecb HIV: kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t HIV l\u00e2u d\u00e0i c\u00f3 th\u1ec3 kh\u00f4ng ph\u1ee5 thu\u1ed9c ho\u00e0n to\u00e0n v\u00e0o vi\u1ec7c t\u1ea1o ra m\u1ed9t h\u1ec7 mi\u1ec5n d\u1ecbch kh\u00e1ng HIV nh\u1edd \u0111\u1ed9t bi\u1ebfn CCR5\u039432\/\u039432.<\/strong><\/span><\/p>\n

M\u1ed9t tr\u01b0\u1eddng h\u1ee3p \u0111\u1eb7c bi\u1ec7t sau gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c<\/span><\/h2>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u m\u00f4 t\u1ea3 m\u1ed9t ng\u01b0\u1eddi \u0111\u00e0n \u00f4ng 60 tu\u1ed5i s\u1ed1ng chung v\u1edbi HIV v\u00e0 m\u1eafc b\u1ec7nh b\u1ea1ch c\u1ea7u c\u1ea5p d\u00f2ng t\u1ee7y (AML)<\/strong>. \u0110\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0 m\u00e1u, \u00f4ng \u0111\u01b0\u1ee3c gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u d\u1ecb gen (allogeneic hematopoietic stem-cell transplantation \u2013 allo-HSCT<\/em>).<\/span><\/p>\n

\u0110i\u1ec3m \u0111\u1eb7c bi\u1ec7t n\u1eb1m \u1edf ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng.<\/span><\/p>\n

C\u1ea3 ng\u01b0\u1eddi nh\u1eadn v\u00e0 ng\u01b0\u1eddi hi\u1ebfn \u0111\u1ec1u mang ki\u1ec3u gen CCR5 wild-type\/CCR5\u039432<\/strong>, t\u1ee9c ch\u1ec9 c\u00f3 m\u1ed9t b\u1ea3n sao CCR5\u039432<\/strong>. V\u00ec v\u1eady, c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch m\u1edbi \u0111\u01b0\u1ee3c t\u1ea1o ra sau gh\u00e9p v\u1eabn c\u00f3 CCR5 ho\u1ea1t \u0111\u1ed9ng v\u00e0 kh\u00f4ng ho\u00e0n to\u00e0n kh\u00e1ng HIV<\/strong>.<\/span><\/p>\n

\u0110\u00e2y l\u00e0 \u0111i\u1ec3m kh\u00e1c bi\u1ec7t quan tr\u1ecdng so v\u1edbi nh\u1eefng tr\u01b0\u1eddng h\u1ee3p ch\u1eefa tr\u1ecb HIV n\u1ed5i ti\u1ebfng tr\u01b0\u1edbc \u0111\u00e2y, trong \u0111\u00f3 ng\u01b0\u1eddi hi\u1ebfn th\u01b0\u1eddng mang hai b\u1ea3n sao CCR5\u039432\/\u039432<\/strong>. \u0110\u1ed9t bi\u1ebfn n\u00e0y l\u00e0m m\u1ea5t bi\u1ec3u hi\u1ec7n CCR5 tr\u00ean b\u1ec1 m\u1eb7t t\u1ebf b\u00e0o v\u00e0 t\u1ea1o ra m\u1ee9c \u0111\u1ed9 kh\u00e1ng \u0111\u00e1ng k\u1ec3 \u0111\u1ed1i v\u1edbi nhi\u1ec1u ch\u1ee7ng HIV s\u1eed d\u1ee5ng CCR5 \u0111\u1ec3 x\u00e2m nh\u1eadp t\u1ebf b\u00e0o.<\/span><\/p>\n

Sau kho\u1ea3ng 3 n\u0103m k\u1ec3 t\u1eeb khi gh\u00e9p<\/strong>, ng\u01b0\u1eddi b\u1ec7nh ng\u1eebng \u0111i\u1ec1u tr\u1ecb kh\u00e1ng retrovirus (ART).<\/span><\/p>\n

\u0110i\u1ec1u \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 sau \u0111\u00f3, t\u00ecnh tr\u1ea1ng kh\u00f4ng ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c HIV v\u1eabn \u0111\u01b0\u1ee3c duy tr\u00ec trong h\u01a1n 6 n\u0103m<\/strong>. HIV RNA trong huy\u1ebft t\u01b0\u01a1ng ti\u1ebfp t\u1ee5c \u1edf d\u01b0\u1edbi ng\u01b0\u1ee1ng ph\u00e1t hi\u1ec7n. C\u00e1c x\u00e9t nghi\u1ec7m chuy\u00ean s\u00e2u c\u0169ng kh\u00f4ng t\u00ecm th\u1ea5y virus HIV c\u00f3 kh\u1ea3 n\u0103ng sao ch\u00e9p trong nh\u1eefng m\u1eabu m\u00e1u v\u00e0 m\u00f4 ru\u1ed9t \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u.<\/span><\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u v\u1eabn th\u1eadn tr\u1ecdng khi di\u1ec5n gi\u1ea3i k\u1ebft qu\u1ea3 v\u00e0 g\u1ecdi \u0111\u00e2y l\u00e0 HIV remission \u2013 thuy\u00ean gi\u1ea3m HIV<\/strong>, thay v\u00ec kh\u1eb3ng \u0111\u1ecbnh \u0111\u01a1n gi\u1ea3n r\u1eb1ng m\u1ecdi d\u1ea5u v\u1ebft HIV \u0111\u00e3 b\u1ecb lo\u1ea1i b\u1ecf ho\u00e0n to\u00e0n.<\/span><\/p>\n

\"\"<\/span><\/p>\n

V\u00ec sao ph\u00e1t hi\u1ec7n n\u00e0y quan tr\u1ecdng?<\/span><\/h2>\n

Trong nhi\u1ec1u n\u0103m, c\u00e2u chuy\u1ec7n v\u1ec1 ch\u1eefa tr\u1ecb HIV th\u01b0\u1eddng g\u1eafn li\u1ec1n v\u1edbi CCR5\u039432\/\u039432<\/strong>.<\/span><\/p>\n

Tr\u01b0\u1eddng h\u1ee3p \u201cBerlin patient\u201d v\u00e0 sau \u0111\u00f3 l\u00e0 \u201cLondon patient\u201d \u0111\u00e3 cho th\u1ea5y gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c t\u1eeb ng\u01b0\u1eddi hi\u1ebfn mang CCR5\u039432\/\u039432 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng ki\u1ec3m so\u00e1t HIV l\u00e2u d\u00e0i sau khi ng\u1eebng ART.<\/span><\/p>\n

T\u1eeb \u0111\u00f3, m\u1ed9t c\u00e2u h\u1ecfi l\u1edbn \u0111\u01b0\u1ee3c \u0111\u1eb7t ra:<\/span><\/p>\n

\n

N\u1ebfu lo\u1ea1i b\u1ecf CCR5 kh\u00f4ng ph\u1ea3i l\u00e0 y\u1ebfu t\u1ed1 duy nh\u1ea5t, th\u00ec \u0111i\u1ec1u g\u00ec th\u1ef1c s\u1ef1 gi\u00fap lo\u1ea1i b\u1ecf ho\u1eb7c ki\u1ec3m so\u00e1t \u1ed5 ch\u1ee9a HIV?<\/strong><\/span><\/p>\n<\/blockquote>\n

Nghi\u00ean c\u1ee9u m\u1edbi tr\u00ean Nature<\/em> cung c\u1ea5p th\u00eam b\u1eb1ng ch\u1ee9ng r\u1eb1ng c\u00e2u tr\u1ea3 l\u1eddi c\u00f3 th\u1ec3 n\u1eb1m \u1edf nhi\u1ec1u c\u01a1 ch\u1ebf ph\u1ed1i h\u1ee3p<\/strong>, ch\u1ee9 kh\u00f4ng ch\u1ec9 \u1edf kh\u1ea3 n\u0103ng kh\u00e1ng HIV c\u1ee7a t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c gh\u00e9p.<\/span><\/p>\n

\u1ed4 ch\u1ee9a HIV m\u1edbi c\u00f3 th\u1ec3 l\u00e0 \u201cm\u1ee5c ti\u00eau trung t\u00e2m\u201d<\/span><\/h2>\n

V\u1ea5n \u0111\u1ec1 l\u1edbn nh\u1ea5t khi\u1ebfn HIV kh\u00f3 \u0111\u01b0\u1ee3c ch\u1eefa kh\u1ecfi b\u1eb1ng ART l\u00e0 thu\u1ed1c c\u00f3 th\u1ec3 ng\u0103n virus nh\u00e2n l\u00ean, nh\u01b0ng kh\u00f4ng lo\u1ea1i b\u1ecf ho\u00e0n to\u00e0n c\u00e1c t\u1ebf b\u00e0o ch\u1ee9a HIV ti\u1ec1m \u1ea9n<\/strong>.<\/span><\/p>\n

Nh\u1eefng t\u1ebf b\u00e0o n\u00e0y t\u1ea1o th\u00e0nh c\u00e1i g\u1ecdi l\u00e0 HIV reservoir \u2013 \u1ed5 ch\u1ee9a HIV<\/strong>.<\/span><\/p>\n

Khi ART b\u1ecb ng\u1eebng, HIV th\u01b0\u1eddng c\u00f3 th\u1ec3 t\u00e1i ho\u1ea1t \u0111\u1ed9ng v\u00e0 virus trong m\u00e1u t\u0103ng tr\u1edf l\u1ea1i. \u0110\u00e2y ch\u00ednh l\u00e0 l\u00fd do ART hi\u1ec7n v\u1eabn ph\u1ea3i \u0111\u01b0\u1ee3c duy tr\u00ec \u1edf ng\u01b0\u1eddi nhi\u1ec5m HIV.<\/span><\/p>\n

Trong tr\u01b0\u1eddng h\u1ee3p \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o n\u0103m 2025, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n b\u1eb1ng ch\u1ee9ng cho th\u1ea5y \u1ed5 ch\u1ee9a HIV \u0111\u00e3 gi\u1ea3m xu\u1ed1ng m\u1ee9c c\u1ef1c k\u1ef3 th\u1ea5p sau gh\u00e9p.<\/span><\/p>\n

Tr\u01b0\u1edbc gh\u00e9p, v\u1eabn c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n HIV proviral c\u00f2n nguy\u00ean v\u1eb9n. Nh\u01b0ng sau gh\u00e9p, c\u00e1c x\u00e9t nghi\u1ec7m chuy\u00ean s\u00e2u tr\u00ean m\u1ed9t l\u01b0\u1ee3ng r\u1ea5t l\u1edbn t\u1ebf b\u00e0o kh\u00f4ng ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c virus c\u00f3 kh\u1ea3 n\u0103ng sao ch\u00e9p.<\/span><\/p>\n

C\u1ee5 th\u1ec3, khi ki\u1ec3m tra h\u01a1n 130 tri\u1ec7u t\u1ebf b\u00e0o CD4 T<\/strong>, x\u00e9t nghi\u1ec7m nu\u00f4i c\u1ea5y virus \u0111\u1ecbnh l\u01b0\u1ee3ng kh\u00f4ng ph\u00e1t hi\u1ec7n virus c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o nhi\u1ec5m m\u1edbi. Ph\u00e2n t\u00edch h\u01a1n 109 tri\u1ec7u t\u1ebf b\u00e0o \u0111\u01a1n nh\u00e2n m\u00e1u ngo\u1ea1i vi (PBMC)<\/strong> ch\u1ec9 ph\u00e1t hi\u1ec7n nh\u1eefng t\u00edn hi\u1ec7u HIV DNA c\u1ef1c k\u1ef3 th\u1ea5p v\u00e0 kh\u00f4ng ch\u1ee9ng minh \u0111\u01b0\u1ee3c s\u1ef1 t\u1ed3n t\u1ea1i c\u1ee7a virus c\u00f3 kh\u1ea3 n\u0103ng sao ch\u00e9p.<\/span><\/p>\n

\"\"<\/span><\/p>\n

C\u1ea5y gh\u00e9p c\u00f3 th\u1ec3 t\u1ea1o ra hi\u1ec7u \u1ee9ng mi\u1ec5n d\u1ecbch ch\u1ed1ng l\u1ea1i \u1ed5 ch\u1ee9a HIV?<\/span><\/h2>\n

M\u1ed9t gi\u1ea3 thuy\u1ebft \u0111\u1eb7c bi\u1ec7t \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 \u201cgraft-versus-HIV-reservoir\u201d<\/strong> \u2013 c\u00f3 th\u1ec3 hi\u1ec3u \u0111\u01a1n gi\u1ea3n l\u00e0 h\u1ec7 mi\u1ec5n d\u1ecbch m\u1edbi t\u1eeb ng\u01b0\u1eddi hi\u1ebfn g\u00f3p ph\u1ea7n nh\u1eadn di\u1ec7n v\u00e0 lo\u1ea1i b\u1ecf nh\u1eefng t\u1ebf b\u00e0o c\u00f2n ch\u1ee9a HIV<\/strong>.<\/span><\/p>\n

Trong qu\u00e1 tr\u00ecnh gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c d\u1ecb gen, h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a ng\u01b0\u1eddi hi\u1ebfn c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c t\u1ebf b\u00e0o c\u00f2n s\u00f3t l\u1ea1i c\u1ee7a ng\u01b0\u1eddi nh\u1eadn.<\/span><\/p>\n

Trong tr\u01b0\u1eddng h\u1ee3p n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u cho r\u1eb1ng ho\u1ea1t t\u00ednh g\u00e2y \u0111\u1ed9c t\u1ebf b\u00e0o ph\u1ee5 thu\u1ed9c kh\u00e1ng th\u1ec3 (antibody-dependent cellular cytotoxicity \u2013 ADCC)<\/strong> kh\u00e1 cao t\u1ea1i th\u1eddi \u0111i\u1ec3m gh\u00e9p c\u00f3 th\u1ec3 \u0111\u00e3 g\u00f3p ph\u1ea7n v\u00e0o vi\u1ec7c l\u00e0m s\u1ea1ch \u1ed5 ch\u1ee9a HIV. \u0110\u1ed3ng th\u1eddi, s\u1ef1 gi\u1ea3m d\u1ea7n c\u1ee7a kh\u00e1ng th\u1ec3 v\u00e0 \u0111\u00e1p \u1ee9ng t\u1ebf b\u00e0o T \u0111\u1eb7c hi\u1ec7u HIV c\u0169ng ph\u00f9 h\u1ee3p v\u1edbi kh\u1ea3 n\u0103ng virus kh\u00f4ng c\u00f2n ho\u1ea1t \u0111\u1ed9ng \u0111\u00e1ng k\u1ec3.<\/span><\/p>\n

N\u00f3i m\u1ed9t c\u00e1ch \u0111\u01a1n gi\u1ea3n:<\/span><\/p>\n

Kh\u00f4ng nh\u1ea5t thi\u1ebft ph\u1ea3i bi\u1ebfn to\u00e0n b\u1ed9 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch th\u00e0nh \u201ct\u01b0\u1eddng th\u00e0nh ch\u1ed1ng HIV\u201d.<\/strong><\/span><\/p>\n

M\u1ed9t chi\u1ebfn l\u01b0\u1ee3c kh\u00e1c c\u00f3 th\u1ec3 l\u00e0:<\/span><\/p>\n

Gi\u1ea3m \u1ed5 ch\u1ee9a HIV th\u1eadt m\u1ea1nh \u2192 lo\u1ea1i b\u1ecf nh\u1eefng t\u1ebf b\u00e0o c\u00f2n ch\u1ee9a virus \u2192 ng\u0103n virus t\u00e1i l\u1eadp qu\u1ea7n th\u1ec3.<\/strong><\/span><\/p>\n

\u0110\u00e2y l\u00e0 m\u1ed9t h\u01b0\u1edbng t\u01b0 duy r\u1ea5t quan tr\u1ecdng \u0111\u1ed1i v\u1edbi nghi\u00ean c\u1ee9u ch\u1eefa tr\u1ecb HIV.<\/span><\/p>\n

Kh\u00f4ng ch\u1ec9 c\u00f3 m\u1ed9t nghi\u00ean c\u1ee9u<\/span><\/h2>\n

\u0110i\u1ec1u \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 ph\u00e1t hi\u1ec7n n\u00e0y kh\u00f4ng xu\u1ea5t hi\u1ec7n ho\u00e0n to\u00e0n \u0111\u01a1n \u0111\u1ed9c.<\/span><\/p>\n

N\u0103m 2024, Nature Medicine<\/em> \u0111\u00e3 b\u00e1o c\u00e1o m\u1ed9t tr\u01b0\u1eddng h\u1ee3p kh\u00e1c: m\u1ed9t ng\u01b0\u1eddi s\u1ed1ng chung v\u1edbi HIV \u0111\u1ea1t t\u00ecnh tr\u1ea1ng thuy\u00ean gi\u1ea3m k\u00e9o d\u00e0i sau allo-HSCT t\u1eeb ng\u01b0\u1eddi hi\u1ebfn c\u00f3 CCR5 ki\u1ec3u b\u00ecnh th\u01b0\u1eddng (wild-type)<\/strong>, t\u1ee9c c\u00e1c t\u1ebf b\u00e0o sau gh\u00e9p v\u1eabn c\u00f3 th\u1ec3 b\u1ecb HIV s\u1eed d\u1ee5ng CCR5 \u0111\u1ec3 x\u00e2m nh\u1eadp. Ng\u01b0\u1eddi b\u1ec7nh kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng HIV t\u00e1i ph\u00e1t trong 32 th\u00e1ng sau khi ng\u1eebng ART t\u1ea1i th\u1eddi \u0111i\u1ec3m b\u00e1o c\u00e1o.<\/span><\/p>\n

Nghi\u00ean c\u1ee9u \u0111\u00f3 \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng v\u00ec n\u00f3 cho th\u1ea5y th\u1eadm ch\u00ed kh\u00f4ng c\u1ea7n CCR5\u039432 trong t\u1ebf b\u00e0o hi\u1ebfn t\u1eb7ng<\/strong>, gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c v\u1eabn c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng thuy\u00ean gi\u1ea3m HIV trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p \u0111\u1eb7c bi\u1ec7t.<\/span><\/p>\n

Tuy nhi\u00ean, \u0111\u00e2y l\u00e0 nh\u1eefng tr\u01b0\u1eddng h\u1ee3p r\u1ea5t hi\u1ebfm v\u00e0 kh\u00f4ng th\u1ec3 \u0111\u01b0\u1ee3c xem l\u00e0 b\u1eb1ng ch\u1ee9ng r\u1eb1ng gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c th\u00f4ng th\u01b0\u1eddng c\u00f3 th\u1ec3 ch\u1eefa HIV.<\/span><\/p>\n

V\u1eady nh\u1eefng c\u01a1 ch\u1ebf n\u00e0o c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2?<\/span><\/h2>\n

T\u1eeb c\u00e1c nghi\u00ean c\u1ee9u hi\u1ec7n nay, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang xem x\u00e9t s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a nhi\u1ec1u y\u1ebfu t\u1ed1:<\/span><\/p>\n

    \n
  • Gi\u1ea3m m\u1ea1nh k\u00edch th\u01b0\u1edbc \u1ed5 ch\u1ee9a HIV<\/strong><\/span><\/li>\n
  • Thay th\u1ebf c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a ng\u01b0\u1eddi nh\u1eadn b\u1eb1ng t\u1ebf b\u00e0o t\u1eeb ng\u01b0\u1eddi hi\u1ebfn<\/strong><\/span><\/li>\n
  • Hi\u1ec7u \u1ee9ng mi\u1ec5n d\u1ecbch d\u1ecb gen gi\u1eefa ng\u01b0\u1eddi hi\u1ebfn v\u00e0 ng\u01b0\u1eddi nh\u1eadn<\/strong><\/span><\/li>\n
  • Kh\u1ea3 n\u0103ng h\u1ec7 mi\u1ec5n d\u1ecbch m\u1edbi lo\u1ea1i b\u1ecf c\u00e1c t\u1ebf b\u00e0o c\u00f2n ch\u1ee9a HIV<\/strong><\/span><\/li>\n
  • ADCC v\u00e0 c\u00e1c c\u01a1 ch\u1ebf mi\u1ec5n d\u1ecbch kh\u00e1c<\/strong><\/span><\/li>\n
  • T\u00ecnh tr\u1ea1ng vi\u00eam v\u00e0 ho\u1ea1t h\u00f3a mi\u1ec5n d\u1ecbch thay \u0111\u1ed5i sau gh\u00e9p<\/strong><\/span><\/li>\n
  • C\u00e1c y\u1ebfu t\u1ed1 \u0111\u1eb7c bi\u1ec7t c\u1ee7a t\u1eebng ng\u01b0\u1eddi b\u1ec7nh, virus v\u00e0 ng\u01b0\u1eddi hi\u1ebfn<\/strong><\/span><\/li>\n<\/ul>\n

    Do \u0111\u00f3, c\u00f3 th\u1ec3 kh\u00f4ng t\u1ed3n t\u1ea1i m\u1ed9t \u201cch\u00eca kh\u00f3a duy nh\u1ea5t\u201d cho ch\u1eefa tr\u1ecb HIV. Thay v\u00e0o \u0111\u00f3, t\u01b0\u01a1ng lai c\u00f3 th\u1ec3 n\u1eb1m \u1edf vi\u1ec7c k\u1ebft h\u1ee3p nhi\u1ec1u c\u01a1 ch\u1ebf \u0111\u1ec3 l\u00e0m cho \u1ed5 ch\u1ee9a HIV nh\u1ecf \u0111\u1ebfn m\u1ee9c h\u1ec7 mi\u1ec5n d\u1ecbch c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t ho\u1eb7c lo\u1ea1i b\u1ecf n\u00f3<\/strong>.<\/span><\/p>\n

    Nh\u01b0ng \u0111\u00e2y c\u00f3 ph\u1ea3i l\u00e0 \u201cthu\u1ed1c ch\u1eefa HIV\u201d d\u00e0nh cho m\u1ecdi ng\u01b0\u1eddi?<\/span><\/h2>\n

    Ch\u01b0a.<\/strong><\/span><\/p>\n

    \u0110\u00e2y l\u00e0 \u0111i\u1ec3m r\u1ea5t quan tr\u1ecdng.<\/span><\/p>\n

    Allo-HSCT l\u00e0 m\u1ed9t th\u1ee7 thu\u1eadt ph\u1ee9c t\u1ea1p, \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ch\u1ee7 y\u1ebfu \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nh\u1eefng b\u1ec7nh l\u00fd nghi\u00eam tr\u1ecdng nh\u01b0 b\u1ec7nh b\u1ea1ch c\u1ea7u ho\u1eb7c m\u1ed9t s\u1ed1 ung th\u01b0 m\u00e1u kh\u00e1c. Quy tr\u00ecnh c\u00f3 th\u1ec3 g\u00e2y ra nhi\u1ec1u bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng, bao g\u1ed3m b\u1ec7nh m\u1ea3nh gh\u00e9p ch\u1ed1ng ch\u1ee7 (GVHD), nhi\u1ec5m tr\u00f9ng v\u00e0 c\u00e1c bi\u1ebfn ch\u1ee9ng li\u00ean quan \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb \u0111i\u1ec1u ki\u1ec7n h\u00f3a<\/strong>.<\/span><\/p>\n

    V\u00ec v\u1eady, kh\u00f4ng th\u1ec3 \u0111\u00e1nh \u0111\u1ed5i nguy c\u01a1 c\u1ee7a gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c ch\u1ec9 \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb HIV \u1edf m\u1ed9t ng\u01b0\u1eddi kh\u00f4ng c\u00f3 ch\u1ec9 \u0111\u1ecbnh gh\u00e9p v\u00ec b\u1ec7nh ung th\u01b0 ho\u1eb7c b\u1ec7nh l\u00fd huy\u1ebft h\u1ecdc kh\u00e1c.<\/span><\/p>\n

    N\u00f3i c\u00e1ch kh\u00e1c:<\/span><\/p>\n

    Nghi\u00ean c\u1ee9u n\u00e0y kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 ng\u01b0\u1eddi nhi\u1ec5m HIV n\u00ean \u0111i gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ec3 ch\u1eefa HIV.<\/strong><\/span><\/p>\n

    \u0110i\u1ec1u c\u00f3 gi\u00e1 tr\u1ecb nh\u1ea5t c\u1ee7a nghi\u00ean c\u1ee9u n\u1eb1m \u1edf vi\u1ec7c n\u00f3 gi\u00fap c\u00e1c nh\u00e0 khoa h\u1ecdc hi\u1ec3u t\u1ea1i sao HIV c\u00f3 th\u1ec3 bi\u1ebfn m\u1ea5t ho\u1eb7c b\u1ecb ki\u1ec3m so\u00e1t l\u00e2u d\u00e0i trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p \u0111\u1eb7c bi\u1ec7t<\/strong>. T\u1eeb \u0111\u00f3, h\u1ecd c\u00f3 th\u1ec3 t\u00ecm c\u00e1ch t\u00e1i t\u1ea1o nh\u1eefng c\u01a1 ch\u1ebf c\u00f3 l\u1ee3i n\u00e0y b\u1eb1ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p an to\u00e0n h\u01a1n.<\/span><\/p>\n

    T\u1eeb \u201cng\u0103n HIV\u201d \u0111\u1ebfn \u201cx\u1eed l\u00fd \u1ed5 ch\u1ee9a HIV\u201d<\/span><\/h2>\n

    Trong nhi\u1ec1u th\u1eadp k\u1ef7, ART \u0111\u00e3 thay \u0111\u1ed5i ho\u00e0n to\u00e0n ti\u00ean l\u01b0\u1ee3ng c\u1ee7a ng\u01b0\u1eddi s\u1ed1ng chung v\u1edbi HIV.<\/span><\/p>\n

    Ng\u00e0y nay, v\u1edbi \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3, HIV c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t l\u00e2u d\u00e0i v\u00e0 ng\u01b0\u1eddi \u0111\u1ea1t t\u1ea3i l\u01b0\u1ee3ng virus d\u01b0\u1edbi ng\u01b0\u1ee1ng ph\u00e1t hi\u1ec7n kh\u00f4ng truy\u1ec1n HIV qua \u0111\u01b0\u1eddng t\u00ecnh d\u1ee5c (U=U)<\/strong>.<\/span><\/p>\n

    Nh\u01b0ng \u0111\u1ed1i v\u1edbi l\u0129nh v\u1ef1c ch\u1eefa tr\u1ecb HIV<\/strong>, m\u1ee5c ti\u00eau c\u00f2n xa h\u01a1n.<\/span><\/p>\n

    C\u00e2u h\u1ecfi kh\u00f4ng ch\u1ec9 c\u00f2n l\u00e0:<\/span><\/p>\n

    \u201cL\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 ng\u0103n HIV nh\u00e2n l\u00ean?\u201d<\/strong><\/span><\/p>\n

    m\u00e0 ng\u00e0y c\u00e0ng tr\u1edf th\u00e0nh:<\/span><\/p>\n

    \u201cL\u00e0m th\u1ebf n\u00e0o \u0111\u1ec3 lo\u1ea1i b\u1ecf ho\u1eb7c ki\u1ec3m so\u00e1t \u1ed5 ch\u1ee9a HIV \u0111\u1ee7 l\u00e2u \u0111\u1ec3 ng\u01b0\u1eddi b\u1ec7nh c\u00f3 th\u1ec3 duy tr\u00ec t\u00ecnh tr\u1ea1ng kh\u00f4ng c\u00f3 virus m\u00e0 kh\u00f4ng c\u1ea7n ART li\u00ean t\u1ee5c?\u201d<\/strong><\/span><\/p>\n

    C\u00e1c tr\u01b0\u1eddng h\u1ee3p gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c \u0111ang cung c\u1ea5p nh\u1eefng \u201cth\u00ed nghi\u1ec7m t\u1ef1 nhi\u00ean\u201d c\u1ef1c k\u1ef3 qu\u00fd gi\u00e1 \u0111\u1ec3 tr\u1ea3 l\u1eddi c\u00e2u h\u1ecfi \u0111\u00f3.<\/span><\/p>\n

    Nghi\u00ean c\u1ee9u Nature<\/em> n\u0103m 2025 cho th\u1ea5y m\u1ed9t \u0111i\u1ec1u \u0111\u1eb7c bi\u1ec7t quan tr\u1ecdng: CCR5\u039432\/\u039432 c\u00f3 th\u1ec3 kh\u00f4ng ph\u1ea3i \u0111i\u1ec1u ki\u1ec7n b\u1eaft bu\u1ed9c \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c t\u00ecnh tr\u1ea1ng thuy\u00ean gi\u1ea3m HIV l\u00e2u d\u00e0i.<\/strong> \u0110i\u1ec1u n\u00e0y m\u1edf r\u1ed9ng \u0111\u00e1ng k\u1ec3 ph\u1ea1m vi c\u00e1c c\u01a1 ch\u1ebf m\u00e0 khoa h\u1ecdc c\u1ea7n nghi\u00ean c\u1ee9u.<\/span><\/p>\n

    T\u01b0\u01a1ng lai c\u00f3 th\u1ec3 kh\u00f4ng ph\u1ea3i l\u00e0 gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c<\/span><\/h2>\n

    M\u1ee5c ti\u00eau cu\u1ed1i c\u00f9ng c\u1ee7a l\u0129nh v\u1ef1c n\u00e0y kh\u00f4ng ph\u1ea3i l\u00e0 \u0111\u01b0a t\u1ea5t c\u1ea3 ng\u01b0\u1eddi nhi\u1ec5m HIV v\u00e0o ch\u01b0\u01a1ng tr\u00ecnh gh\u00e9p t\u1ee7y.<\/span><\/p>\n

    M\u1ee5c ti\u00eau l\u00e0 t\u00ecm ra th\u00e0nh ph\u1ea7n c\u00f3 l\u1ee3i c\u1ee7a qu\u00e1 tr\u00ecnh gh\u00e9p<\/strong> v\u00e0 t\u00e1i t\u1ea1o ch\u00fang b\u1eb1ng nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p an to\u00e0n h\u01a1n.<\/span><\/p>\n

    V\u00ed d\u1ee5, c\u00e1c h\u01b0\u1edbng nghi\u00ean c\u1ee9u hi\u1ec7n nay \u0111ang t\u00ecm c\u00e1ch:<\/span><\/p>\n

      \n
    • l\u00e0m suy gi\u1ea3m ho\u1eb7c lo\u1ea1i b\u1ecf \u1ed5 ch\u1ee9a HIV;<\/span><\/li>\n
    • k\u00edch ho\u1ea1t c\u00e1c t\u1ebf b\u00e0o ch\u1ee9a HIV \u0111\u1ec3 h\u1ec7 mi\u1ec5n d\u1ecbch c\u00f3 th\u1ec3 nh\u1eadn di\u1ec7n;<\/span><\/li>\n
    • t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t t\u1ebf b\u00e0o nhi\u1ec5m HIV;<\/span><\/li>\n
    • t\u1ea1o ra t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng HIV;<\/span><\/li>\n
    • ch\u1ec9nh s\u1eeda gen nh\u01b0 CCR5;<\/span><\/li>\n
    • k\u1ebft h\u1ee3p nhi\u1ec1u chi\u1ebfn l\u01b0\u1ee3c mi\u1ec5n d\u1ecbch v\u00e0 di truy\u1ec1n.<\/span><\/li>\n<\/ul>\n

      C\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng c\u0169ng \u0111ang kh\u00e1m ph\u00e1 nh\u1eefng c\u00e1ch t\u1ea1o ra t\u1ebf b\u00e0o g\u1ed1c t\u1ea1o m\u00e1u c\u00f3 nhi\u1ec1u l\u1edbp b\u1ea3o v\u1ec7 ch\u1ed1ng HIV thay v\u00ec ch\u1ec9 d\u1ef1a v\u00e0o m\u1ed9t c\u01a1 ch\u1ebf duy nh\u1ea5t.<\/span><\/p>\n

      K\u1ebft lu\u1eadn<\/span><\/h2>\n

      Tr\u01b0\u1eddng h\u1ee3p \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean Nature<\/em> kh\u00f4ng ch\u1ee9ng minh r\u1eb1ng \u201ct\u1ebf b\u00e0o g\u1ed1c \u0111\u00e3 ch\u1eefa kh\u1ecfi HIV\u201d<\/strong> theo ngh\u0129a m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 \u00e1p d\u1ee5ng r\u1ed9ng r\u00e3i.<\/span><\/p>\n

      Nh\u01b0ng n\u00f3 cung c\u1ea5p m\u1ed9t m\u1ea3nh gh\u00e9p quan tr\u1ecdng cho b\u1ee9c tranh l\u1edbn h\u01a1n.<\/span><\/p>\n

      M\u1ed9t h\u1ec7 mi\u1ec5n d\u1ecbch m\u1edbi kh\u00f4ng ho\u00e0n to\u00e0n kh\u00e1ng HIV<\/strong> v\u1eabn c\u00f3 th\u1ec3 \u0111i k\u00e8m v\u1edbi t\u00ecnh tr\u1ea1ng thuy\u00ean gi\u1ea3m HIV k\u00e9o d\u00e0i nhi\u1ec1u n\u0103m sau khi ng\u1eebng ART, cho th\u1ea5y vi\u1ec7c lo\u1ea1i b\u1ecf ho\u1eb7c l\u00e0m suy gi\u1ea3m s\u00e2u \u1ed5 ch\u1ee9a HIV v\u00e0 c\u00e1c c\u01a1 ch\u1ebf mi\u1ec5n d\u1ecbch sau gh\u00e9p c\u00f3 th\u1ec3 quan tr\u1ecdng kh\u00f4ng k\u00e9m kh\u1ea3 n\u0103ng kh\u00e1ng virus c\u1ee7a t\u1ebf b\u00e0o hi\u1ebfn t\u1eb7ng<\/strong>.<\/span><\/p>\n

      \u0110\u00e2y c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t b\u01b0\u1edbc chuy\u1ec3n quan tr\u1ecdng trong t\u01b0 duy v\u1ec1 ch\u1eefa tr\u1ecb HIV:<\/span><\/p>\n

      Kh\u00f4ng ch\u1ec9 t\u00ecm c\u00e1ch t\u1ea1o ra m\u1ed9t c\u01a1 th\u1ec3 \u201ckh\u00f4ng th\u1ec3 b\u1ecb HIV nhi\u1ec5m l\u1ea1i\u201d, m\u00e0 t\u00ecm c\u00e1ch khi\u1ebfn HIV kh\u00f4ng c\u00f2n \u0111\u1ee7 kh\u1ea3 n\u0103ng quay tr\u1edf l\u1ea1i.<\/strong><\/span><\/p>\n

      Nghi\u00ean c\u1ee9u v\u1eabn \u0111ang ti\u1ebfp t\u1ee5c. ART v\u1eabn l\u00e0 ti\u00eau chu\u1ea9n \u0111i\u1ec1u tr\u1ecb HIV hi\u1ec7n nay v\u00e0 kh\u00f4ng n\u00ean t\u1ef1 \u00fd ng\u1eebng thu\u1ed1c d\u1ef1a tr\u00ean nh\u1eefng k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u n\u00e0y.<\/strong><\/span><\/p>\n

      Nghi\u00ean c\u1ee9u tham kh\u1ea3o<\/span><\/h3>\n
        \n
      1. Gaebler C, et al. Sustained HIV-1 remission after heterozygous CCR5\u039432 stem cell transplantation<\/em>. Nature<\/strong>. Published online 1 December 2025; 650:701\u2013709 (2026). DOI: 10.1038\/s41586-025-09893-0.<\/span><\/li>\n
      2. S\u00e1ez-Ciri\u00f3n A, et al. Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells<\/em>. Nature Medicine<\/strong>. 2024.<\/span><\/li>\n
      3. HIV-1 remission following stem cell transplant without CCR5\u039432 mutation<\/em>. Nature Medicine<\/strong>. 2024.<\/span><\/li>\n
      4. In-depth virological and immunological characterization of HIV-1 cure after CCR5\u039432\/\u039432 allogeneic hematopoietic stem cell transplantation<\/em>. Nature Medicine<\/strong>. 2023.<\/span><\/li>\n
      5. Multilayered HIV-1 resistance in HSPCs through CCR5 Knockout and B cell secretion of HIV-inhibiting antibodies<\/em>. Nature Communications<\/strong>. 2025.<\/span><\/li>\n<\/ol>\n

        T\u1eeb kh\u00f3a:<\/strong> #Nghi\u00eanC\u1ee9uT\u1ebfB\u00e0oG\u1ed1c #Ch\u1eefaTr\u1ecbHIV #HIVCure #HIVRemission #T\u1ebfB\u00e0oG\u1ed1cT\u1ea1oM\u00e1u #CCR5 #CCR5Delta32 #HIVReservoir #Nghi\u00eanC\u1ee9uHIV #YH\u1ecdcT\u00e1iT\u1ea1o #Li\u1ec7uPh\u00e1pT\u1ebfB\u00e0o #YH\u1ecdcCh\u00ednhX\u00e1c<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

        Li\u1ec7u c\u1ea5y gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c c\u00f3 th\u1ec3 gi\u00fap ng\u01b0\u1eddi nhi\u1ec5m HIV \u0111\u1ea1t tr\u1ea1ng th\u00e1i thuy\u00ean gi\u1ea3m l\u00e2u d\u00e0i m\u00e0 kh\u00f4ng nh\u1ea5t thi\u1ebft ph\u1ea3i s\u1edf h\u1eefu hai b\u1ea3n sao \u0111\u1ed9t bi\u1ebfn CCR5\u039432? M\u1ed9t nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean Nature v\u00e0o th\u00e1ng 12\/2025 \u0111ang mang \u0111\u1ebfn m\u1ed9t g\u00f3c nh\u00ecn quan tr\u1ecdng cho l\u0129nh v\u1ef1c nghi\u00ean […]\n","protected":false},"author":2,"featured_media":2344,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1,9,11],"tags":[],"_links":{"self":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2343"}],"collection":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2343"}],"version-history":[{"count":5,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2343\/revisions"}],"predecessor-version":[{"id":2350,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/2343\/revisions\/2350"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/media\/2344"}],"wp:attachment":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2343"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2343"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}