{"id":875,"date":"2022-03-14T01:58:50","date_gmt":"2022-03-14T01:58:50","guid":{"rendered":"https:\/\/lieuphapyhoctaitao.com\/?p=875"},"modified":"2022-03-14T01:59:53","modified_gmt":"2022-03-14T01:59:53","slug":"hai-con-duong-dan-truyen-tin-hieu-dau-trong-tuy-song-va-nao-bo-gai-doi-thi-moi-va-bo-gai-doi-thi-cu","status":"publish","type":"post","link":"https:\/\/lieuphapyhoctaitao.com\/?p=875","title":{"rendered":"Hai con \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n t\u00edn hi\u1ec7u \u0111au trong t\u1ee7y s\u1ed1ng v\u00e0 n\u00e3o-b\u00f3 gai \u0111\u1ed3i th\u1ecb m\u1edbi v\u00e0 b\u00f3 gai \u0111\u1ed3i th\u1ecb c\u0169"},"content":{"rendered":"

Sau khi v\u00e0o \u0111\u1ebfn t\u1ee7y s\u1ed1ng, t\u00edn hi\u1ec7u \u0111au s\u1ebd theo hai con \u0111\u01b0\u1eddng \u0111i \u0111\u1ebfn n\u00e3o, qua (1) b\u00f3 gai \u0111\u1ed3i th\u1ecb m\u1edbi (neospinothalamic tract) v\u00e0 (2) b\u00f3 gai \u0111\u1ed3i th\u1ecb c\u0169 (paleospinothalamic tract) .<\/span><\/p>\n

B\u00d3 GAI \u0110\u1ed2I TH\u1eca M\u1edaI V\u1edaI \u0110AU NHANH<\/span><\/p>\n

S\u1ee3i th\u1ea7n kinh A\u2206 ch\u1ee7 y\u1ebfu d\u1eabn truy\u1ec1n c\u1ea3m gi\u00e1c \u0111au do c\u01a1 h\u1ecdc v\u00e0 \u0111au c\u1ea5p t\u00ednh do nhi\u1ec7t \u0111\u1ed9, ph\u1ea7n l\u1edbn s\u1ebd t\u1eadn c\u00f9ng t\u1ea1i m\u00e9p ngo\u00e0i c\u00f9ng I (lamina marginalis) \u1edf s\u1eebng sau. T\u1ea1i \u0111\u00e2y, ch\u00fang s\u1ebd k\u00edch th\u00edch neuron ti\u1ebfp theo c\u1ee7a b\u00f3 gai \u0111\u1ed3i th\u1ecb m\u1edbi, l\u00e0 nh\u1eefng s\u1ee3i tr\u1ee5c d\u00e0i, b\u1eaft ch\u00e9o ngay l\u1eadp t\u1ee9c sang n\u1eeda b\u00ean \u0111\u1ed1i di\u1ec7n c\u1ee7a t\u1ee7y s\u1ed1ng qua m\u00e9p tr\u01b0\u1edbc v\u00e0 sau \u0111\u00f3 ch\u1ea1y h\u01b0\u1edbng l\u00ean n\u00e3o trong c\u1ed9t b\u00ean tr\u01b0\u1edbc.<\/span><\/p>\n

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T\u1eadn c\u00f9ng c\u1ee7a b\u00f3 gai \u0111\u1ed3i th\u1ecb m\u1edbi trong n\u00e3o v\u00e0 \u0111\u1ed3i th\u1ecbuy\u1ec1n t\u00edn hi\u1ec7u \u0111au \u0111\u1ebfn h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung <\/em>Ch\u1ec9 m\u1ed9t v\u00e0i s\u1ee3i th\u1ea7n kinh trong b\u00f3 gai \u0111\u1ed3i th\u1ecb m\u1edbi t\u1eadn c\u00f9ng t\u1ea1i v\u00f9ng l\u01b0\u1edbi c\u1ee7a n\u00e3o trong khi ph\u1ea7n l\u1edbn \u0111\u00e3 li\u00ean t\u1ee5c chuy\u1ec3n h\u01b0\u1edbng \u0111i \u0111\u1ebfn \u0111\u1ed3i th\u1ecb v\u00e0 t\u1eadn c\u00f9ng t\u1ea1i ph\u1ee9c h\u1ee3p c\u00e1c nh\u00e2n b\u1ee5ng n\u1ec1n (ventrobasal complex) c\u00f9ng v\u1edbi b\u00f3 thon v\u00e0 b\u00f3 ch\u00eam d\u1eabn truy\u1ec1n c\u1ea3m gi\u00e1c s\u00e2u thu\u1ed9c c\u1ed9t l\u01b0ng t\u1ee7y s\u1ed1ng. C\u0169ng chi c\u00f3 m\u1ed9t s\u1ed1 \u00edt c\u00e1c s\u1ee3i tr\u1ee5c t\u1eadn c\u00f9ng t\u1ea1i nh\u00f3m nh\u00e2n sau trong \u0111\u1ed3i th\u1ecb.<\/span><\/p>\n

Ngo\u00e0i ra, t\u1eeb c\u00e1c v\u00f9ng kh\u00e1c nhau trong \u0111\u1ed3i th\u1ecb, nh\u1eefng t\u00edn hi\u1ec7u s\u1ebd ti\u1ebfp t\u1ee5c truy\u1ec1n t\u1edbi c\u00e1c v\u00f9ng v\u1ecf n\u00e3o kh\u00e1c nhau, ch\u1eb3ng h\u1ea1n nh\u01b0 v\u00f9ng v\u1ecf n\u00e3o c\u1ea3m gi\u00e1c b\u1ea3n th\u1ec3.<\/span><\/p>\n

Kh\u1ea3 n\u0103ng \u0111\u1ecbnh v\u1ecb v\u1ecb tr\u00ed \u0111au nhanh c\u1ee7a h\u1ec7 th\u1ea7n kinh<\/span><\/p>\n

C\u1ea3m gi\u00e1c \u0111au nhanh c\u1ea5p t\u00ednh x\u1ea3y ra \u1edf nh\u1eefng v\u1ecb tr\u00ed tr\u00ean c\u01a1 th\u1ec3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u1ecbnh v\u1ecb nhanh h\u01a1n d\u1ea1ng \u0111au ch\u1eadm m\u1ea1n t\u00ednh. Tuy nhi\u00ean, khi chi c\u00f3 th\u1ee5 th\u1ec3 \u0111au b\u1ecb k\u00edch th\u00edch m\u00e0 kh\u00f4ng c\u00f3 s\u1ef1 k\u00edch th\u00edch \u0111\u1ed3ng th\u1eddi t\u1ea1i c\u00e1c th\u1ee5 th\u1ec3 nh\u1eadn c\u1ea3m x\u00fac gi\u00e1c, \u0111\u1ecba \u0111i\u1ec3m x\u1ea3y ra c\u1ea3m gi\u00e1c \u0111au c\u1ea5p t\u00ednh l\u1ea1i \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh k\u00e9m h\u01a1n, th\u01b0\u1eddng chi nh\u1eadn bi\u1ebft l\u00e0 m\u1ed9t v\u00f9ng r\u1ed9ng 10 cm ho\u1eb7c l\u1edbn h\u01a1n th\u1ebf. N\u00f3i c\u00e1ch kh\u00e1c, n\u1ebfu t\u00e1c nh\u00e2n \u0111\u1ed3ng th\u1eddi t\u1ea1o th\u00eam s\u1ef1 h\u01b0ng ph\u1ea5n v\u1ec1 x\u00fac gi\u00e1c, kh\u1ea3 n\u0103ng \u0111\u1ecbnh v\u1ecb s\u1ebd ch\u00ednh x\u00e1c h\u01a1n.<\/span><\/p>\n

Glutamate \u2013 ch\u1ea5t d\u1eabn truy\u1ec1n c\u1ee7a s\u1ee3i th\u1ea7n kinh a\u2206<\/span><\/p>\n

Glutamate \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 ch\u1ea5t d\u1eabn truy\u1ec1n th\u1ea7n kinh trong t\u1ee7y s\u1ed1ng, t\u1ea1o ra t\u1ea1i \u0111\u1ea7u t\u1eadn c\u1ee7a s\u1ee3i tr\u1ee5c A\u2206. \u0110\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng ch\u1ea5t truy\u1ec1n t\u00edn hi\u1ec7u ph\u1ed5 bi\u1ebfn nh\u1ea5t trong h\u1ec7 th\u1ed1ng th\u1ea7n kinh trung \u01b0\u01a1ng, th\u01b0\u1eddng ho\u1ea1t h\u00f3a trong chi v\u00e0i ph\u1ea7n ng\u00e0n gi\u00e2y.<\/span><\/p>\n

B\u00d3 GAI \u0110\u1ed2I TH\u1eca C\u0168 D\u1eaaN TRUY\u1ec0N C\u1ea2M GI\u00c1C \u0110AU CH\u1eacM M\u1ea0N T\u00cdNH<\/strong><\/span><\/p>\n

B\u00f3 gai \u0111\u1ed3i th\u1ecb c\u0169 thu\u1ed9c h\u1ec7 th\u1ed1ng th\u1ea7n kinh c\u1ed5 \u0111i\u1ec3n, l\u00e0 con \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n \u0111au m\u1ea1n t\u00ednh ch\u1ee7 y\u1ebfu t\u1eeb s\u1ee3i ngo\u1ea1i bi\u00ean c\u1ee7a d\u00e2y th\u1ea7n kinh C, \u0111\u1ed3ng th\u1eddi c\u0169ng c\u00f3 tham gia d\u1eabn truy\u1ec1n m\u1ed9t s\u1ed1 t\u00edn hi\u1ec7u t\u1eeb d\u00e2y A\u2206. Tr\u00ean con \u0111\u01b0\u1eddng n\u00e0y, s\u1ee3i tr\u1ee5c ngo\u1ea1i bi\u00ean t\u1eadn c\u00f9ng t\u1ea1i to\u00e0n b\u1ed9 m\u00e9p II v\u00e0 m\u00e9p III c\u1ee7a s\u1eebng sau t\u1ee7y s\u1ed1ng, g\u1eafn k\u1ebft b\u1eb1ng ch\u1ea5t keo t\u1ee7y s\u1ed1ng (substantia gelatinosa). \u0110a s\u1ed1 t\u00edn hi\u1ec7u s\u1ebd xuy\u00ean qua m\u1ed9t hay nhi\u1ec1u s\u1ee3i neuron ng\u1eafn n\u1ed9i b\u1ed9 trong s\u1eebng sau tr\u01b0\u1edbc khi v\u00e0o \u0111\u1ebfn m\u00e9p V, v\u1eabn c\u00f2n n\u1eb1m trong s\u1eebng sau. \u0110\u00e2y l\u00e0 nh\u1eefng neuron cu\u1ed1i c\u00f9ng cho s\u1ee3i tr\u1ee5c d\u00e0i m\u00e0 ph\u1ea7n l\u1edbn s\u1ebd tham gia c\u00f9ng v\u1edbi nh\u1eefng s\u1ee3i th\u1ea7n kinh t\u1eeb con \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n c\u1ea3m gi\u00e1c \u0111au nhanh. Ch\u00fang s\u1ebd b\u1eaft ch\u00e9o qua m\u00e9p tr\u01b0\u1edbc \u0111\u1ebfn n\u1eeda ph\u1ea7n t\u1ee7y s\u1ed1ng \u0111\u1ed1i b\u00ean, sau \u0111\u00f3 c\u0169ng \u0111i l\u00ean n\u00e3o trong c\u1ed9t tr\u01b0\u1edbc b\u00ean.<\/span><\/p>\n

Ch\u1ea5t p \u2013 ch\u1ea5t d\u1eabn truy\u1ec1n c\u1ea3m gi\u00e1c \u0111au ch\u1eadm m\u1ea1n t\u00ednh c\u1ee7a \u0111\u1ea7u t\u1eadn s\u1ee3i th\u1ea7n kinh<\/strong><\/span><\/p>\n

Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y \u0111\u1ea7u t\u1eadn c\u1ee7a s\u1ee3i th\u1ea7n kinh C t\u1eadn c\u00f9ng trong t\u1ee7y s\u1ed1ng c\u00f3 kh\u1ea3 n\u0103ng b\u00e0i ti\u1ebft ra c\u1ea3 glutamate v\u00e0 ch\u1ea5t P. Glutamate l\u00e0 ch\u1ea5t d\u1eabn truy\u1ec1n ho\u1ea1t \u0111\u1ed9ng t\u1ee9c th\u00ec v\u00e0 chi k\u00e9o d\u00e0i trong v\u00e0i ph\u1ea7n ng\u00e0n gi\u00e2y. Trong khi \u0111\u00f3, ch\u1ea5t P l\u1ea1i \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng ch\u1eadm h\u01a1n nhi\u1ec1u nh\u01b0ng l\u1ea1i c\u00f3 th\u1ec3 duy tr\u00ec n\u1ed3ng \u0111\u1ed9 trong kho\u1ea3ng th\u1eddi gian v\u1ea3i gi\u00e2y hay \u0111\u1ebfn v\u00e0i ph\u00fat. D\u00f9 nh\u1eefng c\u01a1 ch\u1ebf chi ti\u1ebft c\u1ee5 th\u1ec3 v\u1eabn ch\u01b0a gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c, glutamate v\u1eabn \u0111\u01b0\u1ee3c kh\u1eb3ng \u0111\u1ecbnh r\u00f5 r\u00e0ng l\u00e0 ch\u1ea5t d\u1eabn truy\u1ec1n ch\u00ednh y\u1ebfu c\u1ea3m gi\u00e1c \u0111au c\u1ea5p t\u00ednh l\u00ean \u0111\u1ebfn h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng v\u00e0 ch\u1ea5t P th\u00ec c\u00f3 vai tr\u00f2 trong \u0111au ch\u1eadm m\u1ea1n t\u00ednh.<\/span><\/p>\n

S\u1ef1 ti\u1ebfp n\u1ed1i gi\u1eefa b\u00f3 gai \u0111\u1ed3i th\u1ecb c\u0169 v\u1edbi n\u00e3o b\u1ed9 v\u00e0 \u0111\u1ed3i th\u1ecb<\/strong><\/span><\/p>\n

Con \u0111\u01b0\u1eddng d\u1eabn truy\u1ec1n c\u1ea3m gi\u00e1c \u0111au ch\u1eadm trong b\u00f3 gai \u0111\u1ed3i th\u1ecb c\u0169 ph\u1ea7n l\u1edbn s\u1ebd t\u1eadn c\u00f9ng trong n\u00e3o. Chi t\u1eeb 1\/10 \u0111\u1ebfn 1\/4 s\u1ed1 s\u1ee3i th\u1ea7n kinh \u0111\u00f3 \u0111i \u0111\u1ebfn \u0111\u1ed3i th\u1ecb. Ba v\u00f9ng t\u1eadn c\u00f9ng nhi\u1ec1u nh\u1ea5t l\u00e0 (1) nh\u00e2n l\u01b0\u1edbi (reticular nuclei) c\u1ee7a h\u00e0nh n\u00e3o, c\u1ea7u n\u00e3o v\u00e0 cu\u1ed1ng n\u00e3o, (2) v\u00f9ng m\u00e1i (tectal area) gian n\u00e3o s\u00e2u \u0111\u1ebfn l\u1ed3i n\u00e3o tr\u00ean v\u00e0 l\u1ed3i n\u00e3o d\u01b0\u1edbi ho\u1eb7c (3) v\u00f9ng ch\u1ea5t x\u00e1m quanh r\u00e3nh Sylvius (periaqueductal gray region). T\u1eeb v\u00f9ng n\u00e3o nh\u1eadn t\u00edn hi\u1ec7u \u0111au, nh\u1eefng neuron c\u00f3 nhi\u1ec1u nh\u00e1nh s\u1ebd ti\u1ebfp n\u1ed1i d\u1eabn truy\u1ec1n l\u00ean \u0111\u1ebfn li\u1ec1m trong (intralaminar), nh\u00e2n b\u1ee5ng b\u00ean (ventrolateral) thu\u1ed9c \u0111\u1ed3i th\u1ecb c\u0169ng nh\u01b0 nh\u1eefng ph\u1ea7n kh\u00e1c c\u1ee7a v\u00f9ng h\u1ea1 \u0111\u1ed3i v\u00e0 nh\u1eefng v\u00f9ng kh\u00e1c c\u1ee7a n\u00e3o.<\/span><\/p>\n

H\u1ea1n ch\u1ebf c\u1ee7a h\u1ec7 th\u1ea7n kinh trong \u0111\u1ecbnh v\u1ecb ngu\u1ed3n t\u00edn hi\u1ec7u \u0111au ch\u1eadm m\u1ea1n t\u00ednh<\/strong><\/span><\/p>\n

Kh\u1ea3 n\u0103ng \u0111\u1ecbnh v\u1ecb v\u1ecb tr\u00ed \u0111au theo con \u0111\u01b0\u1eddng b\u00f3 gai \u0111\u1ed3i th\u1ecb c\u0169 t\u01b0\u01a1ng \u0111\u1ed1i k\u00e9m. Theo \u0111\u00f3, n\u00f3 ch\u1ec9 c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh v\u1ecb tr\u00ed trong kho\u1ea3ng m\u1ed9t v\u00f9ng ch\u00ednh y\u1ebfu c\u1ee7a c\u01a1 th\u1ec3, nh\u01b0 m\u1ed9t c\u1eb3ng tay, m\u1ed9t c\u1eb3ng ch\u00e2n ch\u1ee9 kh\u00f4ng th\u1ec3 l\u00e0 m\u1ed9t \u0111i\u1ec3m c\u1ee5 th\u1ec3 tr\u00ean tay hay ch\u00e2n. Con \u0111\u01b0\u1eddng n\u00e0y ho\u1ea1t \u0111\u1ed9ng tr\u00ean c\u01a1 ch\u1ebf khu\u1ebfch t\u00e1n t\u00edn hi\u1ec7u qua s\u1ef1 g\u1eafn k\u1ebft r\u1ea5t nhi\u1ec1u synapse. \u0110i\u1ec1u n\u00e0y gi\u1ea3i th\u00edch v\u00ec sao b\u1ec7nh nh\u00e2n th\u01b0\u1eddng g\u1eb7p kh\u00f3 kh\u0103n khi \u0111\u01b0\u1ee3c y\u00eau c\u1ea7u ch\u1ec9 ra v\u1ecb tr\u00ed \u0111au trong m\u1ed9t s\u1ed1 d\u1ea1ng \u0111au ch\u1eadm.<\/span><\/p>\n

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Quy\u0301 kha\u0301ch ha\u0300ng, b\u00ea\u0323nh nh\u00e2n va\u0300 ca\u0301c \u0111\u00f4\u0301i ta\u0301c c\u00e2\u0300n t\u01b0 v\u00e2\u0301n, h\u00f4\u0303 tr\u01a1\u0323 v\u00ea\u0300 chuy\u00ean \u0111\u00ea\u0300 tr\u00ean xin vui lo\u0300ng li\u00ean h\u00ea\u0323:<\/span><\/b><\/td>\n<\/tr>\n
\"\"<\/span><\/a>Hotline ba\u0301c si\u0303<\/span><\/a><\/td>\n\n

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Zalo ba\u0301c si\u0303<\/a><\/p>\n<\/td>\n

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Nh\u0103\u0301n tin ba\u0301c si\u0303<\/a><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Sau khi v\u00e0o \u0111\u1ebfn t\u1ee7y s\u1ed1ng, t\u00edn hi\u1ec7u \u0111au s\u1ebd theo hai con \u0111\u01b0\u1eddng \u0111i \u0111\u1ebfn n\u00e3o, qua (1) b\u00f3 gai \u0111\u1ed3i th\u1ecb m\u1edbi (neospinothalamic tract) v\u00e0 (2) b\u00f3 gai \u0111\u1ed3i th\u1ecb c\u0169 (paleospinothalamic tract) . B\u00d3 GAI \u0110\u1ed2I TH\u1eca M\u1edaI V\u1edaI \u0110AU NHANH S\u1ee3i th\u1ea7n kinh A\u2206 ch\u1ee7 y\u1ebfu d\u1eabn truy\u1ec1n c\u1ea3m gi\u00e1c \u0111au […]\n","protected":false},"author":1,"featured_media":557,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/875"}],"collection":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=875"}],"version-history":[{"count":1,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/875\/revisions"}],"predecessor-version":[{"id":876,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/posts\/875\/revisions\/876"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=\/wp\/v2\/media\/557"}],"wp:attachment":[{"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lieuphapyhoctaitao.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}